Ultrasound-guided transversalis fascia plane block for pain after inguinal lymph node dissection

Evaluation of Peri-operative Analgesic Efficacy of Ultrasound Guided Transversalis Fascia Plane Block in Cancer Patients Undergoing Inguinal Lymph Node Dissection: A Prospective Randomized Controlled Study

This will test whether an ultrasound-guided transversalis fascia plane block can reduce pain and opioid needs for adult cancer patients having inguinal lymph node removal.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 90 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: National Cancer Institute, Egypt (Academic / other)
• Locations: 1 site (Cairo)
• Trial ID: NCT07331129 on ClinicalTrials.gov

What this trial studies

This interventional trial compares an ultrasound-guided transversalis fascia plane block to surgical-site local anesthetic infiltration for postoperative pain control in adults undergoing inguinal lymph node dissection. The block is performed under ultrasound guidance to target the transversalis fascia plane and the study will track pain scores, opioid consumption, and common opioid-related side effects after surgery. Eligible participants are cancer patients aged 18–65 with ASA class I–II and BMI between 20 and 40 kg/m2, without major bleeding risk or unstable cardiovascular disease. The work is conducted at the National Cancer Institute, Cairo University with standard perioperative monitoring and follow-up.

Who should consider this trial

Good fit: Adults aged 18–65 with cancer scheduled for inguinal lymph node dissection who are ASA I–II and have a BMI of 20–40 kg/m2, and who do not have infection at the puncture site, significant coagulopathy, unstable heart disease, or allergies to the anesthetics used.

Not a fit: Patients with local infection at the puncture site, platelets below 50,000 or INR >1.6, unstable cardiovascular disease, severe psychiatric/cognitive disorders, or allergy to the study medications would not be eligible and are unlikely to benefit from this procedure.

Why it matters

Potential benefit: If successful, the block could provide better pain control after surgery while reducing opioid use and opioid-related side effects.

How similar studies have performed: Related abdominal wall and fascial-plane blocks such as TAP and TFPB have shown reduced postoperative pain and opioid use in hernia and other abdominal surgeries, but use of TFPB specifically for inguinal lymph node dissection is less well studied.

Eligibility criteria

Inclusion Criteria:

1. American society of anesthesiologists (ASA) class I and II.
2. Age ≥ 18 and ≤ 65 Years.
3. Cancer patients for inguinal lymph node dissection.
4. Body mass index (BMI): \> 20 kg/m2 and \< 40 kg/m2.

Exclusion Criteria:

1. Patient refusal.
2. Local infection at the puncture site.
3. Coagulopathies with platelets count below 50,000 or an INR\>1.6.
4. Unstable cardiovascular disease.
5. History of psychiatric and cognitive disorders.
6. Patients allergic to medication used.

Where this trial is running

Cairo

• National Cancer Institute Cairo University — Cairo, Egypt (Recruiting)

Study contacts

• Principal investigator: Ayman Sharawy Abdel Rahman Aboul Nasr, MD — National Cancer Institute Cairo University
• Study coordinator: Ayman Sharawy Abdel Rahman Aboul Nasr, MD

Conditions Inguinal Lymph Nodes Enlarged; transversalis fascia plane block; ultrasound; inguinal lymph node dissection