Ultrasound-guided radiofrequency treatment for knee osteoarthritis pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of ultrasound-guided genicular nerve radiofrequency ablation therapy in patients with chronic knee pain due to osteoarthritis. It compares the outcomes of different treatment protocols involving 2, 3, and 5 nerve ablations on pain relief, balance, proprioception, and fall risk. The study aims to provide insights into the long-term benefits of these interventions, as current conservative treatments have limited efficacy and potential side effects. By evaluating the impact on multiple symptoms, the research seeks to enhance the understanding of this invasive procedure's role in managing knee osteoarthritis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 30-75
* Chronic knee pain that lasts at least 6 months
* Radiographic confirmation of osteoarthritis: Presence of Grade 3 or 4 radiographic changes characterized by significant narrowing in the medial space of the tibiofemoral joint according to the Kellgren-Lawrence classification system
* Knee pain \>40 mm when performing one of the two movements that cause the most severe pain (sitting to standing or going up and down stairs) according to 100 mm VAS

  * 50% reduction in VAS with diagnostic genicular nerve block

Exclusion Criteria:

* Presence of systemic inflammatory disease such as rheumatoid arthritis
* Previous RFA treatment to the knee or hyaluronic acid or steroid injection to the knee within the last 3 months
* History of previous knee surgery
* Clinically significant structural abnormalities other than osteoarthritis that may lead to chronic knee pain
* Having undergone physical therapy to the knee in the last 6 months or a history of knee trauma
* Application of other pain treatments
* Body-Mass İndex \<18 and \>40 kg/m2
* Pregnancy
* Presence of uncontrolled serious illness (cancer, diabetes, etc.), infection, psychiatric disorder, coagulation disorder

Where it's running

• Ankara Etlik City Hospital, Physical Medicine and Rehabilitation
  Ankara, Ankara, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Bengu Turemenogullari
• Email: drbenguturemen@gmail.com
• Phone: +905072848966

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.