Ultrasound-guided precise disconnection of gastric varices versus endoscopic glue injection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, prospective trial participants with high-risk or recent/active gastric variceal bleeding are assigned to receive either EUS-guided selective variceal devascularization (EUS-SVD) or conventional endoscopic gastric variceal obturation (GVO) with glue. Procedures are performed in hospital with planned observation stays (about 5 days for EUS-SVD, 3 days for GVO). The primary outcome is the one-year gastric variceal re-bleeding rate and secondary outcomes include procedure-related adverse events and safety. Investigators will compare re-bleeding and complication rates to determine whether EUS-SVD provides more durable bleeding control than current standard treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Chinese population aged 18-80 years;
2. High-risk gastric varices confirmed by gastroscopy (for primary prevention) or active bleeding due to gastric varices or a history of acute gastric variceal bleeding within the past 1 month (for secondary prevention);
3. Subjects who prefer endoscopic treatment and voluntarily sign the informed consent form.

Exclusion Criteria:

* (1) Subjects with a history of secondary preventive treatment for gastric varices or shunt surgery; (2) Subjects complicated with hepatorenal syndrome, hepatic encephalopathy grade III/IV, or severe jaundice (serum bilirubin \>10 mg/dl); (3) Subjects complicated with multiple organ failure or advanced malignant tumors; (4) Subjects who are pregnant, in gestation, or lactating; (5) Subjects suspected of having splenic vein or portal vein thrombosis; (6) Subjects with coagulation dysfunction, platelet count \<50,000/mL or INR ≥2; (7) Subjects with esophageal stenosis or a history of esophageal or gastric surgery; (8) Subjects deemed unsuitable for this study by physician evaluation.

Where it's running

• Nanfang Hospital
  Guangzhou, Guangdong, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.