Ultrasound-guided manual vacuum aspiration for managing first trimester miscarriage
Official title: Ultrasound-guided Manual Vacuum Aspiration (USG-MVA)
Run by Chinese University of Hong Kong · NCT05413525 · Data updated 2026-11-12
This study looks at how well ultrasound-guided manual vacuum aspiration works for women experiencing first trimester miscarriages and whether it can help with further testing.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 200 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 2 sites (Hong Kong, Shatin and 1 other locations) |
| Status | Recruiting |
| Started | June 20, 2021 |
| Main results expected | December 30, 2025 |
| Study ends | June 30, 2026 |
| Registry record updated | March 20, 2025 |
| Trial ID | NCT05413525 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include women aged 18 and above who are experiencing a first trimester miscarriage and are suitable for USG-MVA.
✕Probably not a fit
Patients with cervical stenosis, significant uterine abnormalities, or those unable to tolerate pelvic examinations may not benefit from this procedure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study reviews the experience of ultrasound-guided manual vacuum aspiration (USG-MVA) in Hong Kong, focusing on its effectiveness in managing first trimester miscarriages. The study evaluates how USG-MVA can facilitate cytological analysis, which is often challenging after medical evacuation. The procedure uses a hand-held syringe to create suction and can be performed in an outpatient setting with minimal sedation. The investigators have previously established the feasibility and acceptability of this method, having conducted over 200 cases since its introduction in 2015.
Why it matters
Potential benefit: If successful, this approach could provide a safer and more effective option for women experiencing first trimester miscarriages.
How similar studies have gone: Previous studies have shown that ultrasound-guided manual vacuum aspiration is an effective alternative to traditional surgical methods, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women 18 years old or above * Women with miscarriage who are suitable candidates for USG-MVA * first trimester delayed miscarriage ≤ 12 weeks of gestation * incomplete miscarriage with POG ≤ 5cm * hemodynamically stable * tolerates well with speculum examination Exclusion Criteria: * Women who are not feasible for the USG-MVA * cervical stenosis * fibroid uterus ≥12 weeks in size * known uterine malformation * bleeding disorder * suspicion of active infection * inability to tolerate pelvic examination * History of allergy to misprostol or same group of medications
Where it's running
-
Chinese University of Hong Kong
Hong Kong, Shatin, Hong Kong Recruiting -
Union Hospital
Hong Kong, Hong Kong Recruiting
Study contacts
- Study coordinator: Jacqueline Pui Wah Chung
- Email: jacquelinechung@cuhk.edu.hk
- Phone: +852 3505 1537
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Examining Telehealth for Abortion Care and Health Equity
This study tests how using telehealth for abortion care affects costs and follow-up for patients, especially those from underserved communities, compared to in-person visits.
-
Using Letrozole or Mifepristone for Medical Termination of Pregnancy
This study is testing if letrozole can be a more effective and affordable option than mifepristone for women having a medical abortion in the first trimester.
-
Using a new gel to prevent adhesions after first-trimester miscarriage treatment
This study is testing a new gel to see if it can help prevent scar tissue from forming in the uterus after treatment for a miscarriage in the first trimester.
-
Using music therapy to reduce pain and anxiety during early pregnancy loss procedures
This study is testing if music therapy can help reduce pain and anxiety for women undergoing a procedure for early pregnancy loss.
-
Misoprostol versus watchful waiting for retained tissue after first-trimester medical abortion
This project will test whether taking misoprostol or simply watching and waiting works better to clear retained tissue after a first‑trimester medical abortion in women aged 18–45 with ultrasound evidence of retained products.
-
Virtual reality to reduce pain and anxiety during first-trimester procedural abortion
This trial will test whether wearing a VR headset that shows a meditative nature video during a first-trimester procedural abortion reduces pain and anxiety and increases satisfaction compared with usual care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.