Clinical trial Recruiting at 2 sites Observational Ages 18 and up Women only

Ultrasound-guided manual vacuum aspiration for managing first trimester miscarriage

Official title: Ultrasound-guided Manual Vacuum Aspiration (USG-MVA)

Run by Chinese University of Hong Kong · NCT05413525 · Data updated 2026-11-12

This study looks at how well ultrasound-guided manual vacuum aspiration works for women experiencing first trimester miscarriages and whether it can help with further testing.

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment200 (estimated)
SponsorChinese University of Hong Kong
Academic / other
Locations2 sites (Hong Kong, Shatin and 1 other locations)
StatusRecruiting
StartedJune 20, 2021
Main results expectedDecember 30, 2025
Study endsJune 30, 2026
Registry record updatedMarch 20, 2025
Trial IDNCT05413525 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include women aged 18 and above who are experiencing a first trimester miscarriage and are suitable for USG-MVA.

Probably not a fit

Patients with cervical stenosis, significant uterine abnormalities, or those unable to tolerate pelvic examinations may not benefit from this procedure.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study reviews the experience of ultrasound-guided manual vacuum aspiration (USG-MVA) in Hong Kong, focusing on its effectiveness in managing first trimester miscarriages. The study evaluates how USG-MVA can facilitate cytological analysis, which is often challenging after medical evacuation. The procedure uses a hand-held syringe to create suction and can be performed in an outpatient setting with minimal sedation. The investigators have previously established the feasibility and acceptability of this method, having conducted over 200 cases since its introduction in 2015.

Why it matters

Potential benefit: If successful, this approach could provide a safer and more effective option for women experiencing first trimester miscarriages.

How similar studies have gone: Previous studies have shown that ultrasound-guided manual vacuum aspiration is an effective alternative to traditional surgical methods, indicating potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Women 18 years old or above
* Women with miscarriage who are suitable candidates for USG-MVA
* first trimester delayed miscarriage ≤ 12 weeks of gestation
* incomplete miscarriage with POG ≤ 5cm
* hemodynamically stable
* tolerates well with speculum examination

Exclusion Criteria:

* Women who are not feasible for the USG-MVA
* cervical stenosis
* fibroid uterus ≥12 weeks in size
* known uterine malformation
* bleeding disorder
* suspicion of active infection
* inability to tolerate pelvic examination
* History of allergy to misprostol or same group of medications

Where it's running

  • Chinese University of Hong Kong
    Hong Kong, Shatin, Hong Kong
    Recruiting
  • Union Hospital
    Hong Kong, Hong Kong
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.