Ultrasound-guided filler injections for hand rejuvenation

Sonography-Guided Volumetric Rejuvenation on Dorsal Hands: A Split-Hand Randomized Controlled Trial

Not applicable Interventional Chang Gung Memorial Hospital · NCT05819450

This study tests if using ultrasound to guide filler injections can make aging hands look better, especially for women.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment200 (estimated)
Ages18 Years and up
SexAll
SponsorChang Gung Memorial Hospital Academic / other
Locations2 sites (Marbella and 1 other locations)
Trial IDNCT05819450 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the effectiveness of ultrasound-guided volumetric rejuvenation techniques for the dorsal hands. Participants will receive filler injections guided by sonography on one hand, while the other hand will receive a blinded injection for comparison. The study seeks to identify the most suitable fatty layers for injection and assess the feasibility of precise filler placement using ultrasound. The focus is on enhancing the aesthetic appearance of aging hands, particularly in women.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who exhibit aging changes on the dorsal hands.

Not a fit: Patients with a history of severe hand dermatitis, rheumatic arthritis, or previous filler injections to the dorsal hands may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide patients with a more effective and aesthetically pleasing method for hand rejuvenation.

How similar studies have performed: While similar approaches have been explored, this specific method of ultrasound-guided volumetric rejuvenation for the dorsal hands is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of aging changes on the dorsal hands
* Aged ≥18 years

Exclusion Criteria:

* History of severe hand dermatitis
* History of rheumatic arthritis
* History of major hand trauma
* History of limb edema
* History of recent significant weight changes
* History of previous filler injection to the dorsal hands
* History of intravenous catheter insertion and hemodialysis via the forearms or hands

Where this trial is running

Marbella and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions UltrasoundInjection SiteCosmeticVolumetric rejuvenationFillerDorsal hand
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.