Clinical trial Recruiting at 1 site Interventional Ages 21 to 65

Ultrasound-guided EXORA (external oblique and rectus abdominis plane) block for pain and stress in umbilical hernia repair

Official title: The Effect of Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery: A Prospective Randomized Controlled Trial

Run by Tanta University · NCT07324863 · Data updated 2026-11-12

This trial will test whether adding an ultrasound-guided EXORA block to general anesthesia reduces surgical stress hormones and postoperative pain after elective umbilical hernia repair in adults.

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Quick facts

Study typeInterventional
Ages21 Years to 65 Years
SexAll
Enrollment100 (estimated)
SponsorTanta University
Academic / other
Locations1 site (Tanta)
StatusRecruiting
StartedAugust 1, 2025
Main results expectedSeptember 1, 2026
Study endsSeptember 1, 2026
Registry record updatedJanuary 8, 2026
Trial IDNCT07324863 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 21–65 years with ASA physical status I–II who are scheduled for elective umbilical hernia repair under general anesthesia.

Probably not a fit

Patients with ASA III–IV, metabolic disorders (like diabetes), those on corticosteroids, with coagulation problems, anatomical abnormalities, complicated/obstructed hernias, or allergy to local anesthetics are excluded and unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for elective umbilical hernia repair under general anesthesia will receive either standard general anesthesia alone or general anesthesia plus an ultrasound-guided external oblique and rectus abdominis plane (EXORA) block. Researchers will measure neuroendocrine stress markers and postoperative analgesia using hormonal assays and pain scoring at defined time points before and after surgery. The EXORA block is a fascial plane technique intended to numb the anterolateral abdominal wall and may complement or fill gaps left by other blocks such as QLB or ESP. Outcomes will include differences in hormonal stress response and measures of postoperative opioid requirement and pain control.

Why it matters

Potential benefit: If successful, the EXORA block could reduce the hormonal stress response and postoperative pain, potentially lowering opioid needs and improving recovery after umbilical hernia repair.

How similar studies have gone: Other fascial plane blocks (e.g., TAP, QLB, ESP) have demonstrated postoperative analgesic benefit, but the EXORA block is an emerging technique with limited direct outcome data to date.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged from 21 to 65 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.
* Schedule for elective umbilical hernia surgery under general anesthesia.

Exclusion Criteria:

* ASA Ⅲ or Ⅳ.
* Patients with metabolic abnormalities, e.g., diabetes mellitus.
* Patients receiving corticosteroids.
* History of allergies to local anesthetics.
* Bleeding or coagulation disorders.
* Anatomical abnormalities.
* Psychiatric and neurological disorders.
* Complicated hernial defect (obstructed).
* Patient refusal.

Where it's running

  • Tanta University
    Tanta, Egypt
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.