Ultralow-dose PET imaging of somatostatin receptor 2 (SSTR2) uptake

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants will receive a very small amount of the FDA-approved radiotracer 68Ga-Dotatate (less than about 1/20th of the standard dose) and be imaged on a new high-sensitivity PET scanner for up to three hours. Investigators will vary injection-to-scan timing, scan duration, and image reconstruction methods to determine how low the radiation dose can be reduced while preserving image quality. The study will enroll roughly 200 adults, including healthy volunteers and people with neuroendocrine tumors, and will compare tracer uptake patterns across groups. Outcomes will focus on image quality and ability to detect SSTR2-expressing lesions at ultralow doses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years.
* Ability to provide informed consent and comply with study procedures.
* For female participants: Must not be pregnant or breastfeeding; Negative pregnancy test required for women of childbearing potential.

Exclusion Criteria:

* Participants who have exceeded NRC regulation for annual radiation exposure from prior research-related scans, including this study (50 millisievert \[mSv\] total).
* More than four prior enrollments in this study.
* Participants with severe claustrophobia, chronic pain, or musculoskeletal conditions that prevent completion of the PET scan
* Medication \& Prior Treatment Exclusions: SSTR targeted therapies
* Pregnant or breastfeeding individuals (negative pregnancy test required)
* Inability to provide informed consent
* Any condition that, in the investigator's judgment, may compromise participant safety or study integrity.

Where it's running

• Nuclear Imaging Institute
  Englewood, New Jersey, United States Recruiting

Study contacts

• Study coordinator: Barbara Blanchfield
• Email: bblanchfield@nii.org
• Phone: 9732554955

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.