Two ways to support breathing during ventilator weaning in adults
Official title: Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Critically Ill Adults: A Cluster-Randomized, Cluster-Crossover Trial
Run by Rush University Medical Center · NCT07005505 · Data updated 2026-11-12
This will test whether automatic tube compensation or pressure support ventilation helps adults on a ventilator for more than 24 hours get their breathing tube removed successfully.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 880 (estimated) |
| Sponsor | Rush University Medical Center Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | July 2027 |
| Study ends | August 2027 |
| Registry record updated | October 28, 2026 |
| Trial ID | NCT07005505 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) admitted to the ICU who have been on invasive mechanical ventilation for at least 24 hours and who pass the spontaneous breathing trial screening are ideal candidates.
✕Probably not a fit
Patients with tracheostomies, Do-Not-Intubate orders, pregnancy, prisoners, or those not being considered for extubation would not be eligible or likely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cluster-randomized, cluster-crossover trial at Rush University Medical Center compares pressure support ventilation (PSV) and automatic tube compensation (ATC) during spontaneous breathing trials for critically ill adults who have received invasive mechanical ventilation for at least 24 hours. Clinical units alternate which SBT mode is used as standard care, and eligible patients who pass the SBT screen receive the assigned mode as part of routine weaning. The trial tracks successful extubation after the SBT as the main outcome and records reintubation and other clinical outcomes. Both PSV and ATC are used in practice, and the trial aims to determine which mode leads to more reliable ventilator liberation.
Why it matters
Potential benefit: If one mode proves better, it could increase successful extubation rates and shorten time on mechanical ventilation, lowering related complications.
How similar studies have gone: Smaller physiologic studies and limited clinical trials suggest ATC can reduce work of breathing, but large randomized comparisons of ATC versus PSV for extubation outcomes are lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Admitted to intensive care unit (ICU) * Age 18 years or older * Requiring invasive mechanical ventilation for at least 24 hours * Pass spontaneous breathing trial screen criteria Exclusion Criteria: * Do not intubate (DNI) order * Presence of tracheostomy * Pregnancy * Known prisoner * Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures * Enrolled in another clinical trial that impacts ventilator weaning or liberation * Receive veno-venous extracorporeal membrane oxygenation (VV-ECMO)
Where it's running
-
Rush University Medical Center
Chicago, Illinois, United States Recruiting
Study contacts
- Study coordinator: Jie Li, PhD
- Email: Jie_Li@rush.edu
- Phone: 312-563-4643
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.