Two varnishes for dentin hypersensitivity: fluoride-containing vs fluoride-free
Official title: Effectiveness of Two Different Desensitizing Dental Varnishes: A Prospective, Randomized Split Mouth Clinical Investigation
Run by Ivoclar Vivadent AG · NCT07622043 · Data updated 2026-11-12
This study tests whether a fluoride-containing dental varnish reduces dentin hypersensitivity more than a fluoride-free varnish in adults with non-carious, vital teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | Ivoclar Vivadent AG Industry-sponsored |
| Locations | 1 site (Schaan) |
| Status | Recruiting |
| Started | July 13, 2026 |
| Main results expected | April 2027 |
| Study ends | August 2027 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07622043 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 with dentin hypersensitivity affecting two non-adjacent teeth in different quadrants and no recent dental restorations on those teeth.
✕Probably not a fit
Individuals whose hypersensitivity does not improve after varnish application or who have confounding factors affecting pain perception may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two varnishes applied to sensitive teeth to assess their ability to reduce dentin hypersensitivity over time. Participants receive either a fluoride-containing varnish or a fluoride-free placebo varnish, with outcomes measured for short- and long-term relief and patient-reported experiences. Safety and tolerability of both varnishes are monitored. Eligible adults aged 18 to 65 with non-neighboring sensitive teeth in different quadrants are enrolled after informed consent. Exclusion criteria include known allergies to varnish components, pregnancy, systemic disease, recent desensitizing therapy, and other factors that could affect pain perception or treatment safety.
Why it matters
Potential benefit: If successful, patients with dentin hypersensitivity may experience longer-lasting relief from sensitivity with the fluoride varnish.
How similar studies have gone: Prior varnish-based approaches have shown reductions in sensitivity, but direct comparison of fluoride-containing versus fluoride-free varnishes provides new, more specific evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed Consent signed by the subject * Age: 18-65 years * Hypersensitivity assessment scale ≥ Grade 2 in * two non-neighboring teeth in different quadrants * The affected teeth are/have: vital, caries-free, received no restorations within the last month * No change in medication anticipated over the next 3 months (e.g. due to upcoming surgery etc.) Exclusion Criteria: * Contraindications and limitations of the MD as described in the instructions for use. * Known hypersensitivity or allergy to the device material (especially acrylates, mint flavouring) * Pregnant or other vulnerable subjects * Participants with severe systemic disease * Enrolment of employees of the dental clinic of Ivoclar Vivadent AG * Recent change in medication concerning Analgesics, NSAIDs, psychotropic drugs, other medications that may alter pain perception * Intake of analgesics prior to appointment * Professional desensitizing therapy in the last 3 months * Bleaching procedures in the last 4 weeks * Confounding dental conditions at test sites: defective or extensive restorations, abutment teeth for prostheses, recent restorations, pulpitis/periapical pathology. * Current or recent use of desensitizing toothpastes or mouthrinses (i.e. products specifically marketed for the treatment of dentin hypersensitivity) within 4 weeks prior to enrolment
Where it's running
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Internal Clinic Ivoclar Vivadent AG
Schaan, Liechtenstein Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.