Two-Stage Sinus Lift with Osseodensification: Allograft vs Autogenous-Xenograft in Severely Atrophic Posterior Maxilla
Official title: Evaluation of 2 Stage Transcrestal Maxillary Sinus Lift With Osseodensification Using Allograft Versus Autogenous-Xenograft in Severely Atrophic Posterior Maxilla: A Radiographic and Histomorphometric Study
Run by Cairo University · NCT07813910 · Data updated 2026-11-12
This trial tests whether using allograft alone or a mix of autogenous bone and xenograft during a two-stage osseodensification sinus lift helps people with very little bone height in the upper jaw.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Giza, Giza Governorate) |
| Status | Recruiting |
| Started | June 6, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | February 28, 2027 |
| Registry record updated | September 15, 2026 |
| Trial ID | NCT07813910 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–70 with RBH 0–4 mm in the severely atrophic posterior maxilla and at least 7 mm of bone width, in good general health and able to undergo surgery.
✕Probably not a fit
Patients with uncontrolled systemic disease, active sinus or dental infections, heavy smoking, or anatomical factors preventing osseodensification may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, controlled study comparing two grafting approaches used during two-stage crestal sinus lifting with osseodensification for patients with severely atrophic posterior maxillae (RBH 0–4 mm). Participants are assigned 1:1 to receive either allograft alone or a combination of autogenous bone and xenograft. The first stage uses osseodensification drills to elevate the sinus floor and place the assigned graft incrementally, with CBCT imaging immediately after surgery and at six months. In the second stage, during implant placement, bone-core biopsies will be taken for histomorphometric analysis and primary implant stability will be measured by insertion torque. The study is conducted at Cairo University’s Oral and Maxillofacial Surgery Outpatient Clinic in Egypt.
Why it matters
Potential benefit: If successful, the grafting approach could improve bone formation and implant stability for patients with very limited residual bone height.
How similar studies have gone: Previous similar approaches have shown promise in bone augmentation techniques, but this exact two-arm comparison in osseodensification–assisted sinus lifts is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Eligibility Criteria Inclusion Criteria: Participants must: 1. Be 18-70 years old. 2. Have a severely atrophic posterior maxilla with RBH 0-4 mm confirmed by CBCT. 3. Have adequate bone width of minimum 7 mm. 4. Be in good health status and able to undergo surgery. 5. Provide informed consent and agree to follow study instructions. Exclusion Criteria: Patients with: 1. Uncontrolled systemic diseases, immunosuppression, history of head \& neck radiotherapy or chemotherapy. 2. Use of bisphosphonates, antiresorptive\*\*,\*\* or antiangiogenic drugs. 3. Pregnancy. 4. Heavy smoking (\>10 cigarettes/day). 5. Active sinus disease, oral infection, untreated periodontal disease, or severe bruxism. 6. Poor oral hygiene. 7. Anatomical issues such as sinus septa or inadequate ridge width preventing the OD approach. 8. Previous sinus lift or implant failure in the same site.
Where it's running
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Cairo university hospital
Giza, Giza Governorate, Egypt Recruiting
Study contacts
- Principal investigator: Reham M Mahrous, BDS — Faculty of dentisitry, Cairo university
- Study coordinator: Reham M Mahrous, BDS
- Email: reham.mahrous@dentistry.cu.edu.eg
- Phone: 01289103950
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.