Two-hand face-mask hold (C-E vs V-E) during general anesthesia
Official title: Effectiveness of Facial Mask Non-Invasive Ventilation in Adults Under General Anesthesia: Two-Hand C-E vs V-E Techniques. A Double-Blind Randomized Trial
Run by Universidad de Antioquia · NCT07179432 · Data updated 2026-11-12
This will test whether the two-hand C-E or V-E face-mask hold helps adults under general anesthesia breathe more effectively.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 206 (estimated) |
| Sponsor | Universidad de Antioquia Academic / other |
| Locations | 2 sites (Medellín, Antioquia and 1 other locations) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | March 1, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | September 17, 2025 |
| Trial ID | NCT07179432 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 scheduled for elective surgery under general anesthesia who consent and do not have predictors of difficult mask ventilation or need supplemental oxygen are appropriate candidates.
✕Probably not a fit
People with predicted difficult airways, obstructive sleep apnea, a beard, ASA class IV or higher, oxygen saturation below 92% on admission, or anyone requiring supplemental oxygen are excluded and unlikely to benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
On the day of elective surgery, after the patient is asleep under general anesthesia, the clinician will use one of two two-hand mask-holding techniques (C-E or V-E) for a short period. Investigators will record how well the patient is ventilated, measure end-tidal carbon dioxide, and collect the clinician's rating of ease and comfort using each technique. No other aspects of the planned surgery or recovery will be changed by participation. The trial is being conducted at Universidad de Antioquia–affiliated clinical sites in Medellín, Colombia.
Why it matters
Potential benefit: If one technique works better, it could make mask ventilation safer and easier during anesthesia and emergency airway care, potentially reducing airway-related problems.
How similar studies have gone: Previous comparisons of mask-holding techniques have been performed but show mixed results, so direct head-to-head trials like this are still needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients over 18 years old * Scheduled for elective surgery * Require general anesthesia * Consent to participate in the study Exclusion Criteria: * Presence of predictors of difficult ventilation: presence of a beard, --obstructive sleep apnea/hypopnea syndrome * Anticipated difficult airway * Classified as ASA IV or higher * Oxygen saturation less than 92% upon admission * Requirement for supplemental oxygen
Where it's running
-
Hospital alma Mater de Antioquia
Medellín, Antioquia, Colombia Recruiting -
Antioquia´s University
Medellín, Colombia Recruiting
Study contacts
- Principal investigator: Mario Zamudio, Anesthesiologist — Universidad de Antioquia
- Study coordinator: Mario Zamudio, Anesthesiologist
- Email: mario.zamudio@udea.edu.co
- Phone: +57 3003456596
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.