Tubeless VATS (non‑intubated anesthesia) for mediastinal tumor removal
Official title: A Randomized Controlled Trial of Non-intubated Versus Intubated VATS for Mediastinal Neoplasm
Run by The First Affiliated Hospital of Guangzhou Medical University · NCT07065604 · Data updated 2026-11-12
This trial will test whether VATS without intubation is as safe and effective as the standard intubated approach for adults having mediastinal tumor surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 132 (estimated) |
| Sponsor | The First Affiliated Hospital of Guangzhou Medical University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | March 26, 2025 |
| Main results expected | May 1, 2028 |
| Study ends | August 31, 2028 |
| Registry record updated | July 15, 2025 |
| Trial ID | NCT07065604 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–80 years with a mediastinal neoplasm ≤6 cm on chest CT, ASA I–III, without evidence of adjacent organ invasion or distant metastasis, who can give informed consent.
✕Probably not a fit
Patients with tumor invasion of adjacent organs, pleural or pericardial dissemination, lymphatic/hematogenous metastases, concurrent active malignancies, significant uncontrolled cardiac disease, or those outside the 18–80 age range are unlikely to benefit from the tubeless approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial compares non‑intubated (tubeless) VATS with conventional intubated VATS for resection of mediastinal neoplasms. Eligible adult patients with tumors ≤6 cm and ASA class I–III are randomized to receive either non‑intubated or intubated anesthesia and undergo standard thoracoscopic resection. The study collects perioperative and surgical outcomes (operative time, complications, need for conversion to intubation, length of stay) and includes follow‑up to capture oncologic outcomes. The aim is to determine whether tubeless VATS provides comparable short‑term safety and similar long‑term cancer outcomes to the conventional technique.
Why it matters
Potential benefit: If successful, tubeless VATS could reduce anesthesia‑related risks, shorten recovery and hospital stay, and improve patient comfort after mediastinal tumor surgery.
How similar studies have gone: Observational and nonrandomized studies have supported the safety and feasibility of non‑intubated thoracic procedures including VATS, but randomized evidence for mediastinal tumor resections is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Mediastinal neoplasm was diagnosed by chest enhanced CT 2. The patients with age ≥ 18 and ≤ 80 years old 3. The patients whose tumor diameter was \<6 cm 4. ASA grade: I-III 5. The patients should understand the research and sign the informed consent Exclusion Criteria: 1. Imaging examinations revealed that the tumor had invaded adjacent organs, with evidence of pleural or pericardial dissemination, as well as lymphatic and/or hematogenous metastases 2. Patients with a confirmed history of congestive heart failure, poorly controlled angina despite medical therapy, electrocardiogram-confirmed myocardial infarction with transmural involvement, uncontrolled hypertension, clinically significant valvular heart disease, or high-risk arrhythmias not adequately managed 3. Patients with concurrent active malignancies
Where it's running
-
the First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Shuben Li, Deputy Director
- Email: 13500030280@163.com
- Phone: 86(020) 8306 2114
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Visual feedback in inspiratory muscle training after lobectomy
This study tests whether adding a mobile app with visual feedback to inspiratory muscle training helps lung cancer patients after lobectomy by improving motivation, adherence, and comfort while breathing.
-
Adding a serratus anterior plane block to a rhomboid intercostal block for pain control after VATS
We will try adding a serratus anterior plane block to the usual rhomboid intercostal block for adults having VATS to see if it reduces postoperative pain and opioid use within 48 hours.
-
Investigating reasons for longer hospital stays after lung surgery
This study looks at why some patients stay in the hospital longer after lung surgery and aims to find ways to improve their recovery.
-
Improving chest tube and pain management after surgery for spontaneous pneumothorax
This study is testing whether taking out chest tubes right after surgery for a collapsed lung can help patients recover faster and feel less pain compared to keeping them in for several days.
-
Treatment for lung cancer using targeted chemotherapy delivery
This study is testing a new way to deliver chemotherapy directly to lung tumors in patients with hard-to-treat lung cancer to see if it helps control tumor growth better than standard treatments.
-
Pre-incisional ropivacaine plus diprospan to relieve pain after VATS
This study tests whether injecting ropivacaine with diprospan before surgery can reduce postoperative pain for adults and children undergoing VATS lung surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.