Triple-combination therapy for HR+/HER2- advanced breast cancer after progression on standard treatment

An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard Therapy

This study will test whether adding L-ornithine L-aspartate to a CDK4/6 inhibitor plus fulvestrant helps people with HR-positive/HER2-negative advanced breast cancer who have progressed after CDK4/6 inhibitor and endocrine therapy.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Ages: 18 Years and up
• Sex: Female
• Sponsor: Fudan University (Academic / other)
• Drugs / interventions: chemotherapy, immunotherapy
• Locations: 1 site (Shanghai)
• Trial ID: NCT07117630 on ClinicalTrials.gov

What this trial studies

This open-label, Bayesian adaptive Phase 2 study gives a CDK4/6 inhibitor together with fulvestrant and L-ornithine L-aspartate to adults with HR+/HER2- advanced breast cancer who progressed on prior CDK4/6 inhibitor and endocrine therapy. The Bayesian adaptive design allows interim looks at accumulating data and possible design updates based on safety and early efficacy signals. Eligible patients must have at least one measurable lesion per RECIST v1.1 and adequate organ function. The trial will primarily monitor tumor response and safety outcomes at Fudan University Shanghai Cancer Center.

Who should consider this trial

Good fit: Adults with histologically confirmed HR-positive/HER2-negative advanced breast cancer who progressed after CDK4/6 inhibitor plus endocrine therapy, have measurable disease by RECIST 1.1, and adequate organ function are the intended candidates.

Not a fit: Patients without HR+/HER2- disease, those who have not received prior CDK4/6 inhibitors, those lacking measurable lesions, or those with poor organ function are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, this combination could extend disease control and delay progression for patients whose HR+/HER2- advanced breast cancer has stopped responding to prior CDK4/6 inhibitor and endocrine therapy.

How similar studies have performed: Combining CDK4/6 inhibitors with fulvestrant is an established approach, but adding L-ornithine L-aspartate to try to overcome resistance is a novel strategy with limited prior clinical evidence.

Eligibility criteria

Inclusion Criteria:

* Women aged ≥ 18 years old.
* Patients with histologically confirmed HR+/HER2- invasive breast cancer (specific definition: ER \> 10% tumor cell positivity by immunohistochemistry is defined as ER positive, PR positive, PR \> 10% tumor cell positivity is defined as PR positive; HER2 0 - 1+ or HER2 ++ but negative by FISH without amplification is defined as HER2 negative).
* Patients with HR+/HER2- advanced breast cancer who have experienced disease progression after receiving systemic therapy including CDK4/6 inhibitors and endocrine therapy.
* Patients whom the investigator judges to be suitable for continued endocrine therapy
* Patients with at least one measurable lesion per RECIST version 1.1 criteria (≥ 20 mm on conventional CT scan, ≥ 10 mm on spiral CT scan, and without prior radiotherapy for measurable lesion).
* Patients whose main organs function normally by meeting the following requirements:
* Hematology criteria: HB ≥ 90 g/L (no blood transfusion within 14 days); ANC ≥ 1.5 × 109/L; PLT ≥ 75 × 109/L;
* Blood chemistry criteria: TBIL ≤ 1.5 × ULN (upper limit of normal); ALT and AST ≤ 3 × ULN; if liver metastasis is present, then ALT and AST ≤ 5 × ULN; serum Cr ≤ 1× ULN, endogenous creatinine clearance \> 50 mL/min (Cockcroft-Gault formula);
* Patients who have not received radiotherapy, molecular targeted therapy, or surgery within 3 weeks prior to the start of the study and have recovered from acute toxicities of prior therapies (if a surgery has been undergone, the wound has completely healed); patients who have no peripheral neuropathy or Grade I peripheral neurotoxicity;
* Patients with ECOG score ≤ 2, and life expectancy ≥ 3 months;
* Female subjects of childbearing potential are required to use a medically acceptable method of contraception during study treatment and for at least 3 months after the last dose of study drug;
* Subjects will be enrolled in this study voluntarily, sign the informed consent form (ICF), have good compliance, and cooperate with follow-up.

Exclusion Criteria:

* Patients who have received radiotherapy (except for palliative reasons), chemotherapy, immunotherapy, or bisphosphonates (except for bone metastases) within 3 weeks prior to treatment.
* Patients with uncontrolled central nervous system metastases (defined as symptomatic or requiring the use of corticosteroids or mannitol to control symptoms).
* Patients with a history of clinically important or uncontrolled heart disease, including congestive heart failure, angina pectoris, myocardial infarction within the past 6 months, or ventricular arrhythmia.
* Patients with ongoing ARs ≥ Grade 1 due to prior therapy. Exception to this is alopecia or those that, in the opinion of the investigator, should not be excluded. Such cases should be clearly documented in the investigator's notes.
* Patients who have undergone major surgery (except for minor outpatient surgery, such as placement of vascular access) within 3 weeks of the first course of study treatment.
* Pregnant or lactating patients.
* Patients with a history of malignancy (except for cured basal cell carcinoma of the skin and carcinoma in situ of the cervix) within the past five years.
* Inability to swallow, chronic diarrhea and intestinal obstruction, there are multiple factors affecting the taking and absorption of drugs.
* Presence of a third space effusion (such as large pleural fluid and ascites) that cannot be controlled by drainage or other methods.
* Long-term unhealed wounds or incompletely healed fractures.
* Patients with known HBV or HCV infection active phase or hepatitis B DNA ≥ 500, or chronic phase with abnormal liver function.
* Those with allergies, or those who are known to have a history of allergy to the drug components of this study.

Where this trial is running

Shanghai

• Fudan University Shanghai Cancer Center — Shanghai, China (Recruiting)

Study contacts

• Study coordinator: Zhiming Shao, Professor

Conditions Breast Cancer