Triclosan-coated versus standard absorbable stitches after lower impacted wisdom tooth removal
Evaluation of Soft Tissue Healing and Antibacterial Effectiveness of Triclosan-Coated Polyglactin 910 Sutures After Impacted Mandibular Third Molar Surgery: A Randomized Double-Blind Split-Mouth Clinical Trial
This trial will test whether triclosan-coated absorbable stitches help soft-tissue healing and reduce bacteria after lower impacted wisdom tooth removal in adults 18 to 35.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | University of Medicine and Pharmacy at Ho Chi Minh City Academic / other |
| Locations | 1 site (Ho Chi Minh City) |
| Trial ID | NCT07386366 on ClinicalTrials.gov |
What this trial studies
This is a randomized, double-blind, two-period crossover trial comparing triclosan-coated polyglactin 910 sutures with non-coated polyglactin 910 sutures after impacted mandibular third molar extraction. Each participant has two separate extractions about four weeks apart, receiving one suture type per surgery according to a randomized sequence. Clinical wound-healing is measured and a small suture segment is collected for laboratory bacterial load testing on postoperative days 3, 5, and 7 for each period. Masking of participants and outcome assessors and standardized perioperative management are used to reduce bias and procedural variability.
Who should consider this trial
Good fit: Adults aged 18 to 35 with two similarly impacted mandibular third molars, ASA physical status I or II, no recent antibiotic use, no active local infection, and ability to attend both surgeries and follow-up visits.
Not a fit: Patients who are pregnant or breastfeeding, allergic to study materials, have active infection, have non‑symmetric or unequal difficulty in their impacted molars, or cannot attend the scheduled follow-ups are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, triclosan-coated absorbable stitches could speed early wound healing and reduce bacterial contamination on sutures after lower impacted wisdom tooth extraction.
How similar studies have performed: Triclosan-coated polyglactin sutures have shown reduced bacterial adhesion and modest reductions in surgical-site infections in other surgical specialties, but evidence specific to oral third‑molar surgery is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 35 years. * American Society of Anesthesiologists (ASA) physical status I or II. * Presence of two symmetric impacted mandibular third molars with the same level of difficulty according to the Pell-Gregory and Winter classification; the difference in angulation between the two third molars is no more than 15 degrees. * No use of topical or systemic antibiotics for at least 4 weeks before surgery. * Able and willing to provide written informed consent. * No active infection associated with the mandibular third molar at the time of enrollment. Exclusion Criteria: * Pregnant or breastfeeding. * Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study. * Radiographic findings suggestive of a tumor or cyst associated with the impacted mandibular third molar. * Participant withdraws consent or does not agree to continue participation. * Unable to attend scheduled follow-up visits. * Difference in surgical extraction time between the two procedures is 12 minutes or more. * Suture loss/loosening before completion of the final assessment time point.
Where this trial is running
Ho Chi Minh City
- Specialized Dental Clinic, University of Medicine and Pharmacy at Ho Chi Minh City — Ho Chi Minh City, Vietnam (Recruiting)
Study contacts
- Study coordinator: Le Khanh Huyen Nguyen
- Email: nlkhuyen.ths.rhm24@ump.edu.vn
- Phone: 84981869502
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.