Treatment outcomes for laryngeal and hypopharyngeal carcinoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational cohort follows patients with laryngeal and hypopharyngeal carcinoma staged T1–T4 who receive treatments chosen according to 2020 NCCN guidelines. Early-stage patients (T1–T2) may receive transoral laser microsurgery, open partial laryngectomy, radiotherapy, or transoral robotic surgery, while advanced-stage patients (T3–T4) may receive surgery with or without adjuvant therapy, concurrent chemoradiotherapy, or neoadjuvant-based combined approaches. The study compares overall survival, disease-specific survival, disease-free survival, local and regional control, and laryngeal function preservation across treatment groups. Data are collected at major Shanghai centers affiliated with Fudan University and Shanghai Jiao Tong University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Laryngeal cancer: glottic type, supraglottic type, and subglottic type; hypopharyngeal cancer: pyriform sinus type, postcri-coid type, and posterior pharyngeal wall type.
* T1, T2, T3, and T4 stage.
* Age 18 - 90.
* Male or female.
* Good compliance.
* No other severe related diseases that may impact the treatment (such as other tumors, severe heart, lung and central nervous system diseases, etc.).
* Negative pregnancy test (for female patients with fertility).
* Male patients with fertility and female patients with fertility and pregnancy risk must agree to use contraceptive methods throughout the study period, and continued until at least 6 months after the last dose of cisplatin. Female patients do not have fertility. Female patients with postmenopausal status.

Exclusion Criteria:

* Patients who have previously been diagnosed with immunodeficiency or known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related diseases.
* Patients with a known history of active tuberculosis (TB).
* Pregnant women or lactating women.
* The doctors believes that it is inappropriate for patients to participate in the trial: having, for example, severe acute or chronic medical conditions (including immune colitis, inflammatory bowel disease, non-infectious pneumonia, pulmonary fibrosis) or mental illness (including recent time \[within the past year\] or active suicidal ideation or behavior).

Where it's running

• Lei Tao
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Lei Tao, Dr.
• Email: doctortaolei@163.com
• Phone: 86 2164377134

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.