Treatment options for fifth metatarsal fractures

Treatment of Fifth Metatarsal Zone 3 Fractures - A Prospective, Randomized, Controlled Trial

NA · Ostfold Hospital Trust · NCT04847115

This study tests whether using a special screw to fix fifth metatarsal fractures helps people walk without pain faster than just using a walking boot.

Quick facts

PhaseNA
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorOstfold Hospital Trust (other)
Locations3 sites (Grålum and 2 other locations)
Trial IDNCT04847115 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of osteosynthesis with intramedullary screw fixation compared to non-operative treatment using a walking boot for patients with Zone 3 fractures of the fifth metatarsal. The aim is to determine which approach allows for faster pain-free weight bearing. Current literature lacks robust evidence, primarily relying on retrospective studies, making this randomized controlled trial essential for strengthening the understanding of treatment options for these fractures.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals diagnosed with Zone 3 fractures of the fifth metatarsal.

Not a fit: Patients with conditions such as neuropathy, open fractures, or those who have had their fracture for more than six months may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide clearer guidelines for treating fifth metatarsal fractures, potentially leading to improved recovery times for patients.

How similar studies have performed: While there has been limited research on this specific treatment comparison, previous studies have indicated varying outcomes for surgical versus non-surgical approaches, highlighting the need for this investigation.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Zone 3 fracture

Exclusion Criteria:

* Neuropathy
* Open fractures
* High energy injuries
* Associated injury in the same or opposite extremity that may affect treatment or rehabilitation
* Pressure ulcer(s)
* Lack of consent competence
* Fracture radiologically confirmed more than six months ago
* No possibility of follow-up at one of the study centers
* Established pseudarthrosis
* Medical condition that contraindicates surgery
* Non-compliance

Where this trial is running

Grålum and 2 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Fractures, Stress, Metatarsal Fracture

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.