Treatment options after targeted therapy stops working in advanced breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This real-world observational project collects retrospective and prospective routine-care data on patients with advanced or metastatic breast cancer who progressed after targeted therapies such as CDK4/6 inhibitors, PIK3CA inhibitors, or trastuzumab deruxtecan (T-DXd). Researchers will record subsequent systemic treatments (chemotherapy, endocrine therapy, targeted agents, or combinations) and capture outcomes including progression-free survival, overall survival, objective response rate, and duration of response. Baseline patient and tumor characteristics, prior treatment history, and follow-up information will be gathered to explore prognostic and predictive factors. The dataset will be used to describe treatment patterns and to develop outcome-prediction models to help guide future sequencing decisions in routine clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults (≥18 years old) with histologically or cytologically confirmed advanced or metastatic breast cancer
2. Received prior treatment with at least one of the following: CDK4/6 inhibitors, PIK3CA inhibitors, trastuzumab deruxtecan (T-DXd), or other targeted therapies
3. Documented disease progression following prior targeted therapy
4. Initiated a subsequent line of systemic therapy (chemotherapy, endocrine therapy, targeted therapy, or combination) after resistance
5. Available clinical data including baseline characteristics and treatment details
6. At least one follow-up evaluation after initiation of post-resistance therapy

Exclusion Criteria:

1. Incomplete medical records or missing key clinical follow-up data
2. Concurrent diagnosis of other active malignancies (except non-melanoma skin cancer or in situ cervical cancer)
3. Known central nervous system disease requiring immediate local treatment (unless clinically stable)
4. Poor general condition with an Eastern Cooperative Oncology Group (ECOG) performance status ≥2
5. Life expectancy estimated to be less than 6 months based on clinical judgment

Where it's running

• Hunan Cancer Hospital
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Binliang Liu, M.D
• Email: liubinliang_onco@163.com
• Phone: +8617370789834

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.