Treatment of warts using heat and hydrogen peroxide
Official title: Rrandomized Controlled Clinical Trial Named Mild Local Hyperthermia and Hydrogen Peroxide Treat Multiple Warts by Targeting a Single Lesion.
Run by First Hospital of China Medical University · NCT06812065 · Data updated 2026-11-12
This study is testing if using heat along with hydrogen peroxide can help people get rid of warts caused by a virus better than using either treatment alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years to 65 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | First Hospital of China Medical University Academic / other |
| Locations | 2 sites (Shenyang, Liaoning and 1 other locations) |
| Status | Recruiting |
| Started | December 7, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 2, 2026 |
| Trial ID | NCT06812065 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 16 to 65 with a clinical diagnosis of viral warts.
✕Probably not a fit
Patients with atypical warts, immunocompromised status, or those who have recently undergone certain treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness and safety of combining local hyperthermia at 44°C with a 3% hydrogen peroxide solution for treating viral warts. The study aims to enhance the immune response against HPV-infected lesions by applying heat, which has been shown to mobilize the body's defenses. Participants will be randomly assigned to receive either the combination treatment or individual treatments to assess comparative efficacy. The trial employs a randomized parallel control design and utilizes statistical methods for data analysis.
Why it matters
Potential benefit: If successful, this treatment could provide a more effective and less painful option for patients suffering from viral warts.
How similar studies have gone: While hyperthermia has been used in other contexts, this specific combination approach with 3% hydrogen peroxide is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: The participants were between 16 and 65 years of age, had a clinical diagnosis of viral warts (including common warts, plantar warts, or condyloma acuminatum), and could understand and sign informed consent. Exclusion criteria: presented with clinically atypical warts; had immunocompromised status or a history of HIV infection; received HPV vaccination within the past 6 months; used immunomodulators, immunosuppressants, or systemic corticosteroids within defined timeframes (4 months and 1 month, respectively); underwent local therapies (e.g., laser, cryotherapy, retinoids) on or near warts within protocol-specified intervals; had a history of cutaneous malignancies or current precancerous lesions; exhibited active dermatologic/systemic diseases (e.g., psoriasis, eczema) or skin conditions (e.g., sunburn) potentially increasing study risks; or were deemed ineligible by investigators for other medical or logistical reasons.
Where it's running
-
Guo Hao
Shenyang, Liaoning, China Recruiting -
infrared hyperthermia device (Patent No: ZL 200820231952.4, Model: YY-WRY-V01, Liaoning Yanyang Medical Instrument Co., Ltd., China)
Shenyang, Liaoning, China Recruiting
Study contacts
- Study coordinator: Hao Guo
- Email: guohao27@126.com
- Phone: +86 13840365892
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Cantharidin and occlusion in verruca epithelium: testing a topical treatment for common warts
This Phase 3 study tests VP-102/TO-208 (cantharidin) vs. a vehicle to see if it clears common warts in people 2 years and older who have a normal immune system.
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Heat combined with a hydrogen peroxide microneedle patch for common warts.
This test will see if applying local heat at 44°C together with a microneedle patch that delivers 3% hydrogen peroxide clears common hand and foot warts in people aged 6 to 65.
-
Long-term follow-up of cantharidin (YCANTH/VP-102/TO-208) treatment for common warts
This follow-up will try applying cantharidin (YCANTH/VP-102/TO-208) every ~21 days for up to four applications to see if it safely clears remaining common warts in people who completed earlier COVE studies.
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Using heat therapy to treat warts in special populations
This study is testing if heat therapy can safely help treat warts in special groups like pregnant women, children, and people with autoimmune diseases or HIV.
-
HPV vaccination for treating stubborn skin warts
This study is testing if the HPV vaccine can help adults with stubborn skin warts get better compared to a placebo.
-
Using Candida antigen and a bivalent HPV vaccine to clear multiple common warts
This study will test whether injections of Candida antigen, a bivalent HPV vaccine, or both can clear multiple common warts in people with persistent or widespread warts.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.