Clinical trial Recruiting at 2 sites Observational

Treatment of Non-small Cell Lung Cancer with Leptomeningeal Metastasis in China

Official title: Database of Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China

Run by Guangzhou Medical University · NCT06718972 · Data updated 2026-11-12

This study looks at how well different treatments work for patients in China with non-small cell lung cancer that has spread to the brain's protective layers, while also checking for safety and survival outcomes.

More Non-Small Cell Lung Cancer trials

Quick facts

Study typeObservational
SexAll
Enrollment1000 (estimated)
SponsorGuangzhou Medical University
Academic / other
Locations2 sites (Guangzhou, Guangdong and 1 other locations)
StatusRecruiting
StartedSeptember 1, 2024
Main results expectedDecember 31, 2028
Study endsDecember 31, 2028
Registry record updatedApril 27, 2025
Trial IDNCT06718972 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients diagnosed with non-small cell lung cancer and leptomeningeal metastasis after January 2018 who have undergone antitumor therapy.

Probably not a fit

Patients with small cell lung cancer components or those with other types of tumors will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to gather data on patients with non-small cell lung cancer (NSCLC) who have developed leptomeningeal metastasis (LM) and have received antitumor therapy since 2018. It will include both retrospective and prospective data from multiple centers in China, focusing on treatment strategies and their efficacy, such as overall survival and time to failure. The study also seeks to evaluate the safety of various treatment approaches and the role of concomitant testing in these patients.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into effective treatment strategies for patients with NSCLC and leptomeningeal metastasis.

How similar studies have gone: While there may be limited data on similar studies, this approach is relatively novel in the context of real-world data collection for this specific patient population.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* non-small cell lung cancer patients with Leptomeningeal metastases diagnosed after January 2018;
* Patients who underwent antitumor therapy after diagnosis of LM.

Exclusion Criteria:

* Patients with small cell lung cancer components;
* complicated with tumors other than non-small cell lung cancer.

Where it's running

  • Guangdong Sanjiu Brain Hospital
    Guangzhou, Guangdong, China
    Recruiting
  • the First Affiliated Hospital of Guangzhou Medical University
    Guangzhou, Guangdong, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.