Treatment of Non-small Cell Lung Cancer with Leptomeningeal Metastasis in China
Official title: Database of Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China
Run by Guangzhou Medical University · NCT06718972 · Data updated 2026-11-12
This study looks at how well different treatments work for patients in China with non-small cell lung cancer that has spread to the brain's protective layers, while also checking for safety and survival outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Guangzhou Medical University Academic / other |
| Locations | 2 sites (Guangzhou, Guangdong and 1 other locations) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | April 27, 2025 |
| Trial ID | NCT06718972 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with non-small cell lung cancer and leptomeningeal metastasis after January 2018 who have undergone antitumor therapy.
✕Probably not a fit
Patients with small cell lung cancer components or those with other types of tumors will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to gather data on patients with non-small cell lung cancer (NSCLC) who have developed leptomeningeal metastasis (LM) and have received antitumor therapy since 2018. It will include both retrospective and prospective data from multiple centers in China, focusing on treatment strategies and their efficacy, such as overall survival and time to failure. The study also seeks to evaluate the safety of various treatment approaches and the role of concomitant testing in these patients.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into effective treatment strategies for patients with NSCLC and leptomeningeal metastasis.
How similar studies have gone: While there may be limited data on similar studies, this approach is relatively novel in the context of real-world data collection for this specific patient population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * non-small cell lung cancer patients with Leptomeningeal metastases diagnosed after January 2018; * Patients who underwent antitumor therapy after diagnosis of LM. Exclusion Criteria: * Patients with small cell lung cancer components; * complicated with tumors other than non-small cell lung cancer.
Where it's running
-
Guangdong Sanjiu Brain Hospital
Guangzhou, Guangdong, China Recruiting -
the First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: hong hai Yang
- Email: bjrf2009@yahoo.com
- Phone: 13711244230
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Patient-specific MRD liquid biopsy for resected NSCLC
This study tests a personalized MRD blood and bronchial washing test after surgery to see if it can signal recurrence earlier in people with resected NSCLC.
-
Osimertinib Plus SRS/SRT for EGFR-Mutant NSCLC with Symptomatic Brain Metastases
This study tests whether adding targeted brain radiotherapy to osimertinib helps control brain metastases in adults with EGFR-mutant NSCLC and neurological symptoms.
-
Dato-DXd in solid tumors (Urothelial Cancer and KRAS-mutant NSCLC) in two sub-studies
This study tests Datopotamab Deruxtecan (Dato-DXd) alone or with other cancer drugs in people with urothelial cancer or KRAS-mutant non-small cell lung cancer.
-
SI-B036 safety test in advanced and metastatic solid tumors
This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.
-
Postoperative EGFR-TKI Therapy for EGFR-mutant NSCLC Following Surgery
This registry tests whether giving an EGFR-TKI after surgery helps adults with EGFR-mutant, high-risk early-stage NSCLC.
-
HS-20093 with Adebrelimab vs HS-20093 alone in advanced non-squamous NSCLC
This study tests whether adding adebrelimab to HS-20093 helps patients with advanced non-squamous NSCLC who have already had treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.