Treatment of malignant pleural effusion with JMKX000197 injection

A Phase Ib, Open Label, Multicenter Clinical Study to Evaluate the Safety, Tolerance, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion

This study is testing a new injection called JMKX000197 to see if it can help people with malignant pleural effusion feel better when combined with a drainage procedure.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Jemincare (Industry-sponsored)
• Locations: 1 site (Beijing)
• Trial ID: NCT06740019 on ClinicalTrials.gov

What this trial studies

This study evaluates the safety, tolerance, pharmacokinetics, pharmacodynamics, and preliminary efficacy of JMKX000197 injection in patients with malignant pleural effusion. Participants will receive the injection along with tube thoracostomy drainage to manage their condition. The study aims to gather data on how well the treatment works and its effects on patients with advanced solid tumors. It is designed for individuals aged 18 to 75 who have been diagnosed with malignant pleural effusion.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with advanced solid tumors and confirmed malignant pleural effusion requiring drainage.

Not a fit: Patients with bilateral malignant pleural effusions or those with a life expectancy of less than three months may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients suffering from malignant pleural effusion.

How similar studies have performed: While this approach is novel, similar studies targeting malignant pleural effusion have shown promise in the past.

Eligibility criteria

Inclusion Criteria:

1. The participant voluntarily joined the study, signed an informed consent form, and had good compliance.
2. Age ≥ 18 years and ≤ 75 years old, regardless of gender.
3. Participants with advanced solid tumors diagnosed by histopathology or cytopathology.
4. Malignant pleural effusion confirmed by histopathology or cytopathology or clinically diagnosed as moderate or above and requiring drainage.
5. Eastern Cooperative Oncology Group (ECOG) performance status: 0 to 2.
6. Life expectancy of at least 3 months.
7. Adequate organ function.
8. Female participants of childbearing potential should agree to use contraception to prevent pregnancy until 6 months after discontinuation of JMKX000197. The serum pregnancy test result should be negative 7 days before enrollment and must be a non-lactating participant. Male participants must agree to use effective contraception during the study and for 6 months after discontinuation of JMKX000197.

Exclusion Criteria:

1. Bilateral pleural effusion or concurrent peritoneal effusion, or concurrent pericardial effusion.
2. Pleural effusion is either encapsulated or severely separated; Or merge with chylothorax; Or combined with infectious pleural effusion.
3. Have used interferon gene stimulating factor (STING) agonists for pleural perfusion。
4. Known allergies to the study drug or its excipient components.
5. Have participated in other clinical trials within 28 days prior to randomization.
6. Major surgery within 28 days prior to randomization.
7. Central nervous system metastatic disease, leptomeningeal disease, or cord compression.
8. Clinical unstable or uncontrolled concomitant cardiovascular, pulmonary, hepatic, renal or seizures diseases.
9. Uncontrollable systemic infections (viruses, bacteria, fungi), including but not limited to positive HBsAg and HBV DNA, positive HCV RNA, positive HIV antibody test or combined infections within the first 28 days of randomization and require systemic anti-infective treatment.
10. Have a history of organ transplantation.
11. Any further condition which, in the opinion of the Investigator, the participant is not suitable in the present study.

Where this trial is running

Beijing

• Cancer Hospital, Chinese Academy of Medical Sciences — Beijing, China (Recruiting)

Study contacts

• Principal investigator: Ning Li — Cancer Institute and Hospital, Chinese Academy of Medical Sciences
• Study coordinator: Fawei Wu

Conditions Malignant Pleural Effusions