Treatment of IgA Nephropathy with SC0062 Capsules

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of SC0062 Capsule in Patients with IgA Nephropathy and Proteinuria (SUCCESS-1)

This study is testing if SC0062 capsules can help people with IgA nephropathy and proteinuria improve their kidney function and reduce protein levels in their urine.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 360 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Biocity Biopharmaceutics Co., Ltd. (Industry-sponsored)
• Drugs / interventions: rituximab
• Locations: 1 site (Guangzhou, Yuexiu District)
• Trial ID: NCT06819826 on ClinicalTrials.gov

What this trial studies

This Phase III clinical trial evaluates the efficacy and safety of SC0062 capsules in patients with IgA nephropathy who have proteinuria. It is a multicenter, randomized, double-blind, placebo-controlled study, meaning participants will be randomly assigned to receive either the SC0062 treatment or a placebo without knowing which they are receiving. Eligible patients must have a high risk of disease progression despite stable use of maximum tolerated doses of RAAS inhibitors and/or SGLT2 inhibitors for at least 12 weeks prior to the trial. The study aims to determine if SC0062 can improve kidney function and reduce proteinuria in these patients.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older with confirmed IgA nephropathy and proteinuria who have been on stable doses of RAAS inhibitors and/or SGLT2 inhibitors for at least 12 weeks.

Not a fit: Patients who do not have IgA nephropathy or those who are not on stable doses of the required background therapies may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve kidney function and reduce the risk of progression to end-stage renal disease in patients with IgA nephropathy.

How similar studies have performed: Other studies have explored treatments for IgA nephropathy, but the specific approach using SC0062 is novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

* Voluntarily sign informed consent and fully understand and comply with trial procedures;
* Age ≥18 years old, gender unlimited;
* IgA nephropathy patients with proteinuria must meet all of the following conditions:

  1. According to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI, 2009) creatinine equation, after 12 weeks of the stable use of the background therapy, the mean of two estimated glomerular filtration rates (eGFR) calculated from central laboratory results was ≥ 30 and \< 90 mL/min/1.73m2.
  2. Received the maximum labeled or tolerated dose of RAASi (ACEI or ARB) for at least 12 weeks before randomization; If subjects were treated with SGLT2i, MRA, or GLP-1RA prior to randomization, the stable use was also required for at least 12 weeks (maximum tolerated and optimal dose determined by the investigator; Subjects who are intolerant to RAASi may also be enrolled).
  3. The pathological examination confirmed IgA nephropathy. Two 24-hour urine samples were collected during the screening period, after 12 weeks of the stable use of the background treatment. Both of the results conducted by the central laboratory were met: 24-hour urine protein to creatinine ratio (UPCR) ≥ 0.75 g/g or 24-hour urinary protein excretion rate (UPER) ≥ 1.0 g.
* Laboratory tests shall meet the following criteria:

  1. Serum albumin ≥ 30 g/L;
  2. Hemoglobin ≥ 90 g/L ; Platelet count ≥80×109/L;
  3. Brain natriuretic peptide (BNP) ≤ 200 pg/mL or N-terminal pro B-type natriuretic peptide (NT-proBNP) ≤ 600 pg/mL;
  4. Blood potassium ≤ 5.5 mmol/L;
  5. Systolic blood pressure (SBP) ≤ 160 mmHg;
  6. Hemoglobin A1c ≤ 8%;
  7. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2×ULN; Total bilirubin ≤ 1.5×ULN;
* During the entire study period from the signing of the informed consent to 3 months after the final administration, fertile females and males who have not received vasectomy should take effective contraceptive measures \[Effective contraceptive measures include: Vasectomy, intrauterine device (IUD), hormones (oral, patch, ring, injection, implant) and barrier methods (diaphragm, cervical cap, sponge, condom).

Exclusion Criteria:

* Pregnant or lactating females; Women of childbearing potential (WOCBP) who have a positive blood pregnancy test before randomization;
* A history of hypersensitivity or allergic to any component of the study drug (SC0062 capsule);
* Systemic use of corticosteroids or immunosuppressants for more than 2 weeks within 3 months prior to randomization; The following are excluded: local topical or intraarticular, intranasal and inhaled glucocorticoids; Use of biological agents (such as rituximab, Telitacicept, etc.), Iptacopan capsules, budesonide enteric-coated capsules within 6 months prior to randomization;
* Concurrent diagnosis of chronic kidney disease caused by other etiologies (including polycystic kidney disease, diabetic kidney disease, or other primary glomerular disease) as determined by the investigator;
* Secondary IgA nephropathy, including but not limited to: Henoch-Schönlein purpura, ankylosing spondylitis, systemic lupus erythematosus, amyloidosis, etc.
* Renal biopsy results showed that \> 25% of glomeruli with crescents, or interstitial fibrosis/tubular atrophy \> 50%;
* Based on KDIGO guidelines, rapidly progressive glomerulonephritis was clinically suspected (judged by the investigator);
* Nephrotic syndrome (UPER \> 3.5g/d and serum albumin \< 30g/L, with or without edema and hyperlipidemia) at screening;
* A history of any lung disease requiring oxygen therapy (e.g., chronic obstructive pulmonary disease, emphysema, pulmonary edema, etc.);
* Use of the same class drug (endothelin receptor antagonist, ERA) before randomization;
* A history of moderate or severe edema, non-traumatic facial edema, or myxedema within the 6 months prior to randomization;
* A history of orthostatic hypotension within 6 months before randomization;
* A history of clinically significant cirrhosis assessed by the investigator;
* A history of worsening heart failure, acute coronary syndrome, transient ischemic attack, stroke and other serious cardiovascular and cerebrovascular diseases within 6 months prior to randomization, or NYHA Grade III to IV at screening;
* A history of kidney or other organ transplantation (except corneal transplantation);
* A condition which had the potential to interfere with oral drug absorption, such as subtotal gastrectomy, clinically severe gastrointestinal disorders, or certain types of bariatric surgery;
* Use of potent CYP3A4 inducers and potent CYP3A4 inhibitors within 2 weeks (14 days) before randomization;
* Received other treatment for IgA nephropathy within 28 days prior to randomization except as permitted by the protocol;
* Active Hepatitis B, active Hepatitis C, active syphilis and Hiv-positive ;
* A history of malignant tumors within 5 years, except for skin squamous cell carcinoma, colon polyp or in situ cervical cancer, thyroid papillary carcinoma;
* A history of alcohol or drug abuse or dependence, or a history of mental illness;
* Participated in clinical trials of other investigational drugs or medical devices within 3 months prior to randomization;
* Any other clinically significant disease, condition, or medical history that may interfere with subjects' safety, study evaluation, and/or study procedures at the discretion of the investigator;
* Any other reasons for not being suitable for participating in this clinical study at the discretion of the investigator.

Where this trial is running

Guangzhou, Yuexiu District

• Guangdong Provincial People's Hospital — Guangzhou, Yuexiu District, China (Recruiting)

Study contacts

• Study coordinator: Yu Xueqing, Prof

Conditions IgA Nephropathy; Endothelin Type A Receptor Antagonist