Treatment of complex anal fistulas using the Fistura® procedure

Radiofrequency Using the Fistura® Procedure for the Treatment of Complex Anal Fistulas: Assessing Healing Rate and Anal Incontinence Up to 1 Year Follow-up

This study is testing if the Fistura® procedure, which uses radiofrequency technology, can help people with complex anal fistulas heal better.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 50 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: F Care Systems NV (Industry-sponsored)
• Drugs / interventions: radiation
• Locations: 1 site (Braine-l'Alleud)
• Trial ID: NCT06113068 on ClinicalTrials.gov

What this trial studies

This study evaluates the healing rate of complex anal fistulas through the Fistura® procedure, which utilizes radiofrequency technology. It is designed as a prospective, interventional, monocenter, single-arm trial, focusing on patients with specific types of complex fistulas. The study aims to gather data on the effectiveness of this innovative treatment approach in promoting healing in affected patients.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older with complex anal fistulas that meet specific criteria.

Not a fit: Patients with simple anal fistulas or those who do not meet the inclusion criteria will likely not benefit from this study.

Why it matters

Potential benefit: If successful, this procedure could significantly improve healing rates for patients suffering from complex anal fistulas.

How similar studies have performed: While the specific Fistura® procedure may be novel, similar approaches using radiofrequency for treating anal fistulas have shown promise in other studies.

Eligibility criteria

Inclusion Criteria:

1. Patients with complex fistulas

   Complex fistulas include trans-sphincteric fistulas involving more than 30% of the external sphincter, supra-sphincteric fistulas, extra-sphincteric fistulas, horseshoe fistulas, fistulas involving multiple tracts (according to the ASCRS) and fistulas with a curved tract or a tract presenting diverticula, for which:

   Suppuration is described by the patient and/or visible by an opening in the anal margin or by anoscopy Clinical symptoms led to an MRI demonstrating the path Fistula path demonstrated in the acute phase during drainage of an abscess
2. Patient ≥ 18 years at study entry
3. Patients with a previously drained fistula, without diverticula \> 10 mm, without T2 hyperintensity (assessed by MRI). Drainage is achieved by placing a seton, usually from 10 weeks to 12 months prior to the procedure
4. Patient and investigator signed and dated the informed consent form prior to the procedure

Exclusion Criteria:

1. Patient \< 18 years at study entry
2. Patient has a known contraindication to treatment using radiofrequency (infectious anal pathologies, anal fissures, residual Longo anterior treatment staples)
3. Patient has a known contraindication to MRI
4. Simple fistulas defined as inter-sphincteric or trans-sphincteric, involving less than 30% of the total height of the sphincter apparatus (attested by MRI, ASCRS classification)
5. Patient has a fistula associated with radiation and inflammatory bowel disease
6. Patient is unable/unwilling to provide informed consent
7. Patient is unable to comply with the protocol or proposed follow-up visits and questionnaires
8. Patient is currently participating in another clinical study
9. Patient is pregnant

Where this trial is running

Braine-l'Alleud

• CHIREC site Braine l'Alleud-Waterloo — Braine-l'Alleud, Belgium (Recruiting)

Study contacts

• Study coordinator: Lauren Swinnen

Conditions Complex Anal Fistulas