Treatment of benign vocal fold lesions using steroid and hyaluronidase injections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of intralesional injections of corticosteroids combined with hyaluronidase for treating minimal associated pathological lesions (MAPLs) of the vocal folds. Patients diagnosed with benign vocal fold lesions and experiencing dysphonia, who are not suitable for surgery or have not responded to voice therapy, will receive these injections via a nasofiberscope. The study aims to improve vocal function and reduce lesion size through this minimally invasive approach. Participants will undergo a series of treatment sessions to assess the outcomes of this intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who are diagnosed with minimal associated pathological lesions and complaining of dysphonia and not fit for surgery.
* Patient not compliant to voice therapy (e.g. those from far residence).
* Patients who refuse voice therapy.
* Patient not responding to voice therapy.

Exclusion Criteria:

* Patients' refusal to be included in the study.
* Patients having any other laryngeal voice disorders.
* Patients not tolerating the naso-endoscopic examination.
* Patients having allergy to the injected material after doing intradermal allergy test.

Where it's running

• Mansoura University - Faculty of Medicine
  Al Mansurah, Dakahlia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Asser Ahmed Elsaeed, Phoniatrics lecturer, M.D, Phd
• Email: asserelsaeed@mans.edu.eg
• Phone: +201005043304

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.