Treatment for reflex syncope using cardioneuroablation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of cardioneuroablation (CNA) on patients suffering from severe reflex syncope characterized by asystolic episodes. CNA aims to eliminate the vagal nerve's influence on heart function, potentially improving heart rate and conduction. The study will assess the acute impacts of total vagal denervation on ECG and electrophysiological parameters, as well as the risk of ventricular arrhythmias in 50 patients undergoing the procedure. Measurements will be taken before and after the CNA intervention to evaluate its effectiveness and safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* severe, recurrent symptoms due to reflex syncope with ECG documented asystole \>3 seconds
* history of ineffective prior non-pharmacological treatment
* positive baseline atropine test (sinus rate acceleration \> 30% and no atrio-ventricular block following 2 mg of intravenous atropine)
* informed written consent to participate in the study

Exclusion Criteria:

* Lack of consent to participate in the study
* Contraindications to perform right ventricular stimulation

Where it's running

• Department of Cardiology, Postgraduate Medical School, Grochowski Hospital
  Warsaw, Poland Recruiting

Study contacts

• Study coordinator: Piotr Kulakowski, MD PhD
• Email: kulak@kkcmkp.pl
• Phone: +48 22 5152757

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Registry for cardioneuroablation in patients with recurrent vasovagal syncope

  This study is collecting information to see how well a new treatment called cardioneuroablation works for people with frequent fainting spells caused by vasovagal syncope.

  Recruiting at 11 sites University Hospital, Bordeaux · Bron and 13 other locations · NCT06159764

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• Assessing counterpressure maneuvers for preventing fainting in children

  This study is testing if teaching children techniques to prevent fainting can help them avoid losing consciousness when they visit the emergency room.

  Recruiting Simon Fraser University · Vancouver, British Columbia · NCT05555771

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.