Treatment for Hepatitis B with Nucleoside Analogues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the efficacy and safety of nucleoside analogues in treating patients with Hepatitis B who have normal levels of Alanine Aminotransferase (ALT) and positive Hepatitis B virus DNA. The research aims to address the gap in current clinical guidelines, which do not recommend antiviral therapy for this patient group despite evidence linking viral replication to increased risks of cirrhosis and liver tumors. By using Tenofovir alafenamide Fumarate, the study seeks to reduce HBV viral load, minimize inflammation, and promote liver cell regeneration. The treatment is noted for its low adverse reaction rate, enhancing its safety profile.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Positive hepatitis b surface antigen and hepatitis b antibody \> 0.5 year;
* Age from 18 to 65 years old;
* Serum Alanine Aminotransferase(ALT) ≤1×ULN at least 12 weeks;
* Positive Hepatitis b virus(HBV);
* Do not receive nucleotide/nucleoside analogues or interferon treatment in the past half year.

Exclusion Criteria:

* Other active liver diseases;
* Hepatocellular carcinoma or other malignancy;
* Pregnancy or lactation;
* Human immunodeficiency virus infection or congenital immune deficiency diseases; 5.Severe diabetes, autoimmune diseases; 6.Other important organ dysfunctions; 7.Using glucocorticoid; 8.Patients can not follow-up; 9.Investigator considering inappropriate.

Where it's running

• Third Affiliated Hospital of Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Liang Peng, Doctor — Third Affiliated Hospital, Sun Yat-Sen University
• Study coordinator: Qiumin Luo, Doctor
• Email: lqiumin@126.com
• Phone: +8613632399075

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.