Treatment for extensive stage extrapulmonary small cell carcinoma using durvalumab with chemotherapy

AGNOSTIC THERAPY IN A PHASE II, MULTICENTER, SINGLE-ARM STUDY IN FIRST-LINE TREATMENT OF DURVALUMAB IN ASSOCIATION WITH CARBOPLATIN OR CISPLATIN AND ETOPOSIDE IN PATIENTS AFFECTED BY EXTENSIVE STAGE - EXTRAPULMONARY SMALL CELL CARCINOMA

This study is testing if a new combination of durvalumab with chemotherapy can help people with advanced extrapulmonary small cell carcinoma feel better and live longer.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 66 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Gruppo Oncologico Italiano di Ricerca Clinica (Academic / other)
• Drugs / interventions: durvalumab, chemotherapy, Radiation, prednisone
• Locations: 1 site (Reggio Emilia)
• Trial ID: NCT06464068 on ClinicalTrials.gov

What this trial studies

This phase II, single-arm, multicenter study evaluates the safety and effectiveness of durvalumab combined with either carboplatin or cisplatin and etoposide in patients with extensive stage extrapulmonary small cell carcinoma. The treatment involves an induction phase of four 21-day cycles followed by a maintenance phase, with patients receiving durvalumab every three to four weeks. The study aims to assess the clinical benefit of this combination therapy, allowing for continuation of treatment even after disease progression if patients show clinical improvement.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with histologically confirmed extensive stage extrapulmonary small cell carcinoma who have not received prior chemotherapy or immune-mediated therapy.

Not a fit: Patients with prior exposure to immune-mediated therapy or chemotherapy for advanced disease may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new effective option for patients with extensive stage extrapulmonary small cell carcinoma.

How similar studies have performed: Other studies have shown promise with similar immunotherapy approaches, but this specific combination is being evaluated for the first time in this patient population.

Eligibility criteria

Inclusion Criteria:

* 1\. Age ≥ 18 years on day of signing informed consent. 2. Written informed consent and any locally required authorization obtained from the patient/legal representative prior to performing any protocol-related procedures, including screening evaluations.

  3\. Histologically or cytologically confirmed extensive disease extrapulmonary small cell carcinoma.

  4\. Brain metastases; must be asymptomatic or treated and stable off steroids and anti-convulsant for at least 1 month prior to study treatment. Patients with suspected brain metastases at screening should have a CT/MRI of the brain prior to study entry. 5. No prior exposure to immune-mediated therapy, including durvalumab excluding therapeutic anticancer vaccines. 6. No prior exposure to chemotherapy for advance disease. 7. Performance status of 0 or 1 on the ECOG Performance Scale. 8. Life expectancy ≥12 weeks at enrollment (day 1). 9. Patients must be considered suitable to receive a platinum-based chemotherapy regimen as first-line treatment for ES-EPSCC. 10. Adequate organ and marrow function, all screening labs should be performed within 14 days of treatment initiation:
  1. Haemoglobin ≥9.0 g/dL
  2. Absolute neutrophil count (ANC) ≥1.0 × 109 /L
  3. Platelet count ≥75 × 109/L
  4. Serum bilirubin ≤1.5 x institutional upper limit of normal (ULN). \<\<This will not apply to patients with confirmed Gilbert's syndrome (persistent or recurrent hyperbilirubinemia that is predominantly unconjugated in the absence of hemolysis or hepatic pathology), who will be allowed only in consultation with their physician.\>\>
  5. AST (SGOT)/ALT (SGPT) ≤2.5 x institutional upper limit of normal unless liver metastases are present, in which
  6. case it must be ≤5x ULN 11. Measured creatinine clearance (CL) \>40 mL/min or Calculated creatinine CL\>40 mL/min by the Cockcroft- Gault formula. 12. Availability of an archived tumor tissue block at baseline. 13. Evidence of post-menopausal status or negative urinary or serum pregnancy test for female premenopausal patients. 14. At least 1 lesion, not previously irradiated, that can be accurately measured at baseline as ≥10 mm in the longest diameter (except lymph nodes, which must have a short axis ≥15 mm) with CT o MRI, suitable for repeated measurements as per RECIST 1.1 criteria. 15. Body weight \>30 kg

     Exclusion Criteria:
* Subjects with active, known or suspected autoimmune disease requiring systemic treatment (systemic steroids or immunosuppressive agents) prior 14 days before the first dose of durvalumab.

The following are exceptions to this criterion:

* Intranasal, inhaled, topical steroids or local steroid injections (eg, intra articular injection).
* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent.
* Steroids as premedication for hypersensitivity reactions (eg, CT scan premedication).
* Premedication with steroids for chemotherapy is acceptable
* Additional malignancy in the last 5 years. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or in situ cervical cancer that has undergone potentially curative therapy.
* Any concurrent chemotherapy, investigational product, biologic, or hormonal therapy for cancer treatment. Concurrent use of hormonal therapy for non-cancer-related conditions (eg, hormone replacement therapy) is acceptable.
* Any history of radiotherapy prior to systemic therapy. Radiation therapy for palliative care (ie, bone metastasis) is allowed but must be completed before first dose of the study medication.
* Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease \[eg, colitis or Crohn's disease\], diverticulitis with the exception of diverticulosis, systemic lupus erythematosus, sarcoidosis syndrome, or Wegener syndrome \[granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis, hypophysitis, and uveitis, etc\]).

The following are exceptions to this criterion:

* Patients with vitiligo or alopecia
* Patients with hypothyroidism (eg, following Hashimoto syndrome) and stable on hormone replacement
* Any chronic skin condition that does not require systemic therapy
* Patients without active disease in the last 5 years may be included but only after consultation with the Study Physician
* Patients with celiac disease controlled by diet alone

  * Major surgical procedure within 28 days prior to the first dose of investigational product. Local surgery of isolated lesions for palliative intent is acceptable.
  * History of leptomeningeal carcinomatosis.
  * History of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies).
  * Active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA \[qualitative\] is detected).
  * Receipt of live, attenuated vaccine within 30 days prior to the first dose of investigational product.

Patients, if enrolled, should not receive live vaccine whilst receiving the investigational product and up to 30 days after the last dose of investigational product.

* Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent
* History of allogenic organ transplantation.
* Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) ≥470 ms calculated from 3 ECGs (within 15 minutes at 5 minutes apart)
* Female patients with a positive pregnancy test at enrollment or prior to administration of study medication
* Female patients who are pregnant or breastfeeding or male or female patients of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose of durvalumab monotherapy (for more information, refer to paragraph 10.8) .

Where this trial is running

Reggio Emilia

• AUSL-IRCCS of Reggio Emilia — Reggio Emilia, Italy (Recruiting)

Study contacts

• Principal investigator: Angela Damato, MD — AUSL/IRCCS of Reggio Emilia
• Study coordinator: Carmine Pinto, MD

Conditions Extrapulmonary Small Cell Carcinoma; EXTRAPULMONARY SMALL CELL CARCINOMA; DURVALUMAB