Treatment for early Dupuytren's disease using vitamin E cream

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of vitamin E cream in preventing the progression of Dupuytren's disease, a condition that causes painful finger contractures. Participants with early-stage Dupuytren's disease will be treated with either vitamin E cream or a placebo, and their condition will be monitored using ultrasound measurements. The goal is to provide evidence for a non-invasive treatment option that could help manage this common hand disorder. The study aims to address the lack of validated non-invasive measurement techniques and effective preventive treatments for Dupuytren's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The participant or his/her legally authorized representative voluntary signed the informed consent prior to the first assessment.
* Participants are ≥ 18 years and diagnosed with primary Dupuytren disease.
* Included patients have a stage 0 DD (nodule of at least 5 mm in the involved hand without contracture).
* The participant has well distinguished noduli that are clearly visible on US (ultrasound)

Exclusion Criteria:

* Patients \< 18 years.
* Patient included in an interventional trial with an investigational medicinal product.
* Patients with cognitive impairments, severe rheumatic disease and neurological disorders leading to flexion deformities of the fingers.
* Patients with prior Dupuytren surgery in the involved hand.
* Patients with a higher Tubiana grading than nodular stage 0.
* Open wound in the palm of the treated hand.

Where it's running

• UZ Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Ilse Degreef, Prof. Dr. — Universitaire Ziekenhuizen KU Leuven
• Study coordinator: Ilse Degreef, Prof. Dr.
• Email: ilse.degreef@uzleuven.be
• Phone: +3216338843

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Investigating the role of micronerves in Dupuytren's disease and their impact on recurrence

  This study looks at whether tiny nerve bundles in the hand affect how often Dupuytren's disease comes back after surgery in people with this condition.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06142929

• Treatment options for Dupuytren's contracture

  This study is testing whether adding a corticosteroid injection to a needle treatment helps people with Dupuytren's contracture move their fingers better.

  Recruiting Phase 4 Regionshospitalet Silkeborg · Silkeborg · NCT05440240

• Evaluating night splinting after needle fasciotomy for Dupuytren's contracture

  This study is testing if wearing a night splint after a needle procedure for Dupuytren's contracture can help prevent the condition from coming back compared to just physical therapy alone.

  Recruiting at 3 sites Uppsala University · Falun, Dalarna County and 2 other locations · NCT05300893

• Surgery with fat grafting for Dupuytren's disease recurrence

  This study is testing whether adding fat grafting to standard surgery for Dupuytren's disease can help prevent the condition from coming back.

  Recruiting at 2 sites Elsan · Pessac and 1 other locations · NCT05067764

• Evaluating post-surgery radiation treatment for Dupuytren's disease

  This study is testing whether adding radiation treatment after surgery for Dupuytren's disease can help improve hand function and reduce symptoms for patients.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04122313

• CNT201 collagenase injection for Dupuytren’s: safety and signals of efficacy in adults

  A randomized, placebo-controlled study will test CNT201 injections to see if they are safe and help improve finger contractures in adults with Dupuytren’s disease.

  Recruiting Phase 1/2 Connext · Kippa-Ring, Queensland · NCT07640425

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.