Treatment for chronic low back pain using pulsed RF neuromodulation and PRP injections
Safety and Efficacy of Pulsed RF Neuromodulation and Leukocyte-Rich PRP for the Treatment of Refractory Low Back Pain Due to Multifidus Dysfunction
This study is testing a new treatment that combines a special type of nerve therapy with platelet-rich plasma injections to see if it can help people with chronic low back pain feel better and move more easily.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 30 Years to 70 Years |
| Sex | All |
| Sponsor | Iffat Anwar Medical Complex Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Trial ID | NCT06524531 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the safety and efficacy of combining pulsed radiofrequency neuromodulation with leukocyte-rich platelet-rich plasma injections for patients suffering from refractory low back pain due to multifidus dysfunction. Participants will be divided into two groups: one receiving the experimental treatment alongside physiotherapy, and the other receiving standard physical therapy alone. The study aims to assess the effectiveness of the new treatment approach in alleviating pain and improving muscle function. The primary outcomes will focus on pain relief and functional improvement over a specified period.
Who should consider this trial
Good fit: Ideal candidates are individuals experiencing refractory low back pain due to multifidus dysfunction for more than six months.
Not a fit: Patients who have had spinal surgery within the last year or are currently on systemic steroids or immunosuppressive medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide significant pain relief and improved function for patients with chronic low back pain.
How similar studies have performed: While there is limited data on this specific combination of treatments, similar approaches using RF neuromodulation and PRP have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Refractory low back pain due to multifidus dysfunction. * Pain persisting for more than 6 months despite conventional treatments. * Ability to provide informed consent. Exclusion Criteria: * Previous spinal surgery within the last year. * Current use of systemic steroids or immunosuppressive medications. * Known bleeding disorders or anticoagulant therapy. * Pregnancy or lactation. * Severe psychiatric or cognitive disorders. * Any Congenital or Non-congenital disorders
Where this trial is running
Lahore, Punjab Province
- Iffat Anwar Medical Complex — Lahore, Punjab Province, Pakistan (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.