Treatment for CD38 Positive T-cell Acute Lymphoblastic Leukemia

A Multicenter, Single-arm Phase II Study to Assess the Safety, Tolerability, and Efficacy of Isatuximab in Adult Patients With Cytologic or Molecular Relapsed/Refractory CD38 Positive T-cell Acute Lymphoblastic Leukemia (GMALL-Isatuximab)

This study is testing if a new drug called Isatuximab can help adults with a tough type of leukemia called CD38 positive T-cell acute lymphoblastic leukemia that has come back or didn’t respond to other treatments.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Goethe University (Academic / other)
• Drugs / interventions: Isatuximab, chemotherapy, immunotherapy, radiation, Cyclophosphamide
• Locations: 14 sites (Augsburg and 13 other locations)
• Trial ID: NCT06648889 on ClinicalTrials.gov

What this trial studies

This trial evaluates the effectiveness of Isatuximab in adult patients with relapsed or refractory CD38 positive T-cell acute lymphoblastic leukemia (T-ALL). It includes two cohorts: one for patients with full cytologic relapse and another for those with molecular failure or minimal residual disease (MRD). The study aims to optimize first-line therapy by modifying standard induction treatment or establishing post-induction therapy to eradicate MRD. Patients will be monitored for their response to the treatment and the presence of blast cells in their bone marrow or blood.

Who should consider this trial

Good fit: Ideal candidates are adults with CD38 positive T-ALL who are either in relapse or have primary refractory disease.

Not a fit: Patients with CD38 negative T-ALL or those who have not undergone prior chemotherapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could improve outcomes for patients with relapsed or refractory T-ALL by providing a more effective therapy option.

How similar studies have performed: Other studies have shown promise with similar approaches targeting CD38 in hematological malignancies, suggesting potential for success in this trial.

Eligibility criteria

Inclusion Criteria:

\- Patients with CD38 positive T-ALL fitting either to the definitions for cohort 1 or cohort 2:

Cohort 1: In relapse or with primary refractory disease defined as ≥5% blasts in bone marrow after at least three chemotherapy cycles (induction I-II, consolidation I) with the following additional specifications:

* early relapse within 12 months from first achievement of CR or
* late relapse later than 12 months from first achievement of CR or
* primary refractory disease without any CR or
* any relapse after stem cell transplantation or
* any refractory relapse, defined as no response to at least one salvage therapy or
* any second or later relapse and
* Availability of patient material with blast cells (bone marrow or peripheral blood) for central MRD assessment or availability of respective predefined marker.

Cohort 2: In complete hematological remission (defined as less than 5% blasts in bone marrow and no evidence of extramedullary disease) after at least three chemotherapy cycles (induction I-II, consolidation I)

* Detection of quantifiable MRD at a level of ≥10-4, either as molecular failure without prior achievement of molecular remission or molecular relapse after prior achievement of molecular remission
* MRD assay at the central reference lab with at least one marker a minimum sensitivity of 10-4
* MRD detection for study inclusion after an interval of at least 2 weeks from last systemic chemotherapy including antibody therapy
* (in patients without clonal molecular MRD marker, MRD testing can be based on flow-cytometry established in reference laboratory)

ECOG status:

* Cohort 1: 0-2
* Cohort 2: 0-1

Age ≥ 18 years Evidence of a personally signed and dated informed consent indicating that the patient has been informed of all pertinent aspects of the study Patient must be willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures

Regeneration from last chemotherapy defined as follows:

Cohort 1:

* Platelets ≥10.000/uL (platelet transfusion allowed)
* Hemoglobin ≥ 7.5 g/dl (red blood cell transfusion allowed)

Cohort 2:

* Neutrophils ≥1.000/uL
* Platelets ≥50.000/uL
* Hemoglobin ≥9 g/dl

Adequate liver function defined as follows:

* Bilirubin ≤ 1.5 ULN (unless Gilbert Meulengracht disease or classified as result of liver infiltration by investigator)
* AST and ALT ≤ 2.5 x ULN (unless classified as result of liver infiltration by investigator)

Adequate renal function defined as follows:

* Serum creatinine ≤ 2 x ULN
* Any serum creatinine level associated with a calculated creatinine clearance ≤ 40 mL/min
* Negative pregnancy test in women of childbearing potential (WOCBP)
* WOCBP must commit to either abstain continuously from heterosexual sexual intercourse or to use 2 methods of reliable birth control simultaneously.
* Men who are sexually active with a WOCBP must agree to use a barrier method of contraception
* Participation in the registry of the German Multicenter Study Group for Adult ALL (GMALL)

Exclusion Criteria:

* Extramedullary involvement except for non-bulky (\<7.5 cm) lymph node involvement, splenomegaly, or hepatomegaly
* Patients who have received prior antileukemic immunotherapy within 2 weeks prior to start of Isatuximab treatment
* Patients who have received treatment for leukemia with chemotherapy as follows:

Cohort 1:

* Patients who have received treatment for leukemia with chemotherapy within 2 weeks prior to start of Isatuximab treatment (exception: pre-phase therapy with 5-7 days of Dexamethasone, 3 days of Cyclophosphamide; intrathecal prophylaxis)
* Patients who are candidates for a treatment with Nelarabine

Cohort 2:

* Any chemotherapy or antibody therapy after the MRD assay leading to study inclusion (exception: intrathecal prophylaxis)
* Patients must have recovered from acute non-hematologic toxicity from previous therapies to ≤ grade I unless signs or symptoms are correlated to leukemia involvement
* Prior SCT ≤ 3 months from start of study treatment
* Acute GvHD ≥ grade II or active chronic GvHD requiring systemic treatment
* Any systemic GvHD prophylaxis or treatment within 2 weeks from start of study treatment
* Known HIV positivity, known hepatitis B surface antigen positivity or known history of hepatitis C
* Unstable or severe uncontrolled medical condition e.g. unstable cardiac function or unstable pulmonary condition
* Treatment with an investigational agent within 4 weeks from start of study treatment (safety follow-up period of respective study)
* Concurrent active malignancy other than non-melanoma skin cancer, carcinoma in situ of the cervix, or localized prostate cancer that has been treated with radiation or surgery; patients with previous malignancies are eligible if they have been disease free for ≥ 2 years and do not require any antitumor therapy.
* Evidence of uncontrolled current serious active infection or recent history (within 4 months) of deep tissue infections such as fasciitis or osteomyelitis
* Known allergies, hypersensitivity, or intolerance to boron or Mannitol, corticosteroids, mAb (including Isatuximab) or human proteins, or their excipients (refer to respective Summary of Product Characteristics), or known sensitivity to mammalian-derived products.
* Active infection, any other concurrent disease or medical condition that are deemed to interfere with the conduct of the study as judged by the investigator
* Pregnant or breastfeeding females
* Vaccination with live attenuated vaccines within 4 weeks of first study agent administration.
* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgement of the investigator, would make the patient inappropriate for entry into this study

Where this trial is running

Augsburg and 13 other locations

• University Hospital Augsburg, II. Medizinischen Klinik, Hämatologie, internistische Onkologie und Hämostaseologie — Augsburg, Germany (Recruiting)
• Charité Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumorimmunologyt Hämatologie — Berlin, Germany (Recruiting)
• Klinikum Carl Gustav Carus Dresden, Medizinische Klinik und Poliklinik I — Dresden, Germany (Recruiting)
• University Hospital Düsseldorf, Department of Hematology, Oncology and Clinical Immunology — Düsseldorf, Germany (Recruiting)
• University Hospital Erlangen AöR, Department of Medicine 5 — Erlangen, Germany (Recruiting)
• Goethe University Hospital Frankfurt, Department of Medicine, Hematology and Oncology — Frankfurt am Main, Germany (Recruiting)
• University Hospital Hamburg-Eppendorf, Department of Medicine II — Hamburg, Germany (Recruiting)
• University Hospital Heidelberg, Department V, Hematology, Oncology and Rheumatology — Heidelberg, Germany (Recruiting)
• University Hospital Schleswig-Holstein, Campus Kiel, Medical Department II — Kiel, Germany (Recruiting)
• University Hospital Leipzig; Klinik für Hämatologie, Zelltherapie, Hämostaseologie und Infektiologie, Bereich Hämatologie und Zelltherapie — Leipzig, Germany (Recruiting)
• University Hospital München-Großhadern, Medizinische Klinik und Poliklinik III — München, Germany (Recruiting)
• University Hospital Münster, Medizinische Klinik A / KMT-Zentrum — Münster, Germany (Recruiting)
• Klinikum Oldenburg AöR, Universitätsklinik für Innere Medizin - Onkologie und Hämatologie — Oldenburg, Germany (Recruiting)
• Robert-Bosch-Krankenhaus; Abteilung für Hämatologie, Onkologie und Palliativmedizin — Stuttgart, Germany (Recruiting)

Study contacts

• Principal investigator: Anjali Cremer, MD — Department of Medicine, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany
• Study coordinator: Nicola Goekbuget, MD

Conditions T-ALL; R/R or MRD CD38-positive T-ALL