Treatment for breast cancer patients with brain metastases using eutideron, etoposide, and bevacizumab

A Single-arm, Open-label， Phase Ⅱ Clinical Trial of Eutideron, Etoposide Combined With Bevacizumab for Breast Cancer Patients With Brain Metastases

This study is testing a new combination of drugs to see if they can help women with breast cancer that has spread to the brain feel better and live longer.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 43 (estimated)
• Ages: 18 Years to 80 Years
• Sex: Female
• Sponsor: Tianjin Medical University Cancer Institute and Hospital (Academic / other)
• Drugs / interventions: bevacizumab, chemotherapy, immunotherapy
• Locations: 1 site (Tianjin, Tianjin)
• Trial ID: NCT05781633 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the efficacy and safety of a combination treatment involving eutideron, etoposide, and bevacizumab in female patients with recurrent metastatic breast cancer that has spread to the brain. Patients will receive a regimen of these drugs over several cycles, with bevacizumab used as maintenance therapy if they show a response or stable disease. The study aims to address the urgent need for effective systemic therapies for patients with brain metastases, as current treatment options are limited. The trial is designed to assess the potential of eutideron, a new anti-tumor drug, to penetrate the blood-brain barrier and improve outcomes for these patients.

Who should consider this trial

Good fit: Ideal candidates are women over 18 with histologically confirmed recurrent metastatic breast cancer and measurable brain lesions.

Not a fit: Patients who have received chemotherapy, radiotherapy, surgery, targeted therapy, or immunotherapy within 4 weeks prior to enrollment may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new effective option for patients with breast cancer that has metastasized to the brain.

How similar studies have performed: While this approach is novel, the use of systemic therapies for brain metastases has shown promise in other studies, indicating potential for success.

Eligibility criteria

Inclusion Criteria:

* Signed informed consent form.
* Female,\>18.
* Histologically or cytologically confirmed recurrent metastatic breast cancer.
* ECOG:0-2.
* There was at least one measurable lesion in the central nervous system.
* Based on screening brain magnetic resonance imaging (MRI), patients with CNS must meet one of the following conditions：
* Untreated brain metastases from breast cancer do not require immediate local treatment.
* Previously treated breast cancer brain metastases that have progressed after previous central nervous system local treatment as assessed by the investigator and that do not have clinical features requiring immediate local treatment.
* Previous anti-HER2 therapy and TKI therapy were required for HER2+ patients.
* Patients who had not received chemotherapy, radiotherapy, surgery, targeted therapy or immunotherapy within 4 weeks before enrollment.
* All toxicity in patients associated with previous antitumor therapy must be restored to ≤ grade 1 (CTCAE v5.0). However, patients with any grade of alopecia were allowed.
* Routine blood tests were normal within 1 week before enrollment (according to the normal range at the participating laboratory):White blood cell count (WBC) ≥ 3.0 × 109/L; Neutrophil count (ANC) ≥ 1.5 × 109/L; Platelet count (PLT) ≥ 100 × 109/L; Hemoglobin ≥ 9.0 g/dL; patients could receive blood transfusions or erythropoietin to meet this criterion.
* Liver and kidney function were basically normal within 1 week before enrollment (based on the normal values of the participating laboratory):Total bilirubin (TBIL) ≤ 2.5× upper limit of normal value (ULN); Alanine aminotransferase (SGPT/ALT) ≤2.5×ULN (≤5×ULN in patients with liver metastases); Aspartate aminotransferase (SGOT/AST) ≤2.5×ULN (≤5×ULN in patients with liver metastases); Creatinine clearance (Ccr) ≥60 ml/min
* Male or female patients of childbearing potential had to consent to use an effective method of contraception, such as dual barrier methods, condoms, oral or injectable contraceptives, intrauterine devices, etc., during the study period and up to 90 days after the last study medication was taken. Female patients of reproductive age had to have a negative blood or urine pregnancy test before enrollment.
* Life expectancy ≥ 12 weeks.

Exclusion Criteria:

* Other malignant tumors (including primary brain or leptomeningeal related tumors) within the past 5 years, except cured basal cell carcinoma of the skin and carcinoma in situ of the cervix;
* Previous anti-tumor therapy, including chemotherapy, radical radiotherapy, hormone therapy, biological therapy, immunotherapy or anti-tumor traditional Chinese medicine therapy within 4 weeks before initiation of study treatment.
* Patients had previously used eutidrone injection, etoposide, or bevacizumab.
* Patients had undergone major organ surgery (excluding needle biopsies) or major trauma within 4 weeks before the first dose of the study drug, or required elective surgery during the trial.
* Patients with ≥grade 3 neurosystem-related severe adverse reactions after previous use of anti-microtubules.
* Patients with any untreated \> 2.0cm brain injury, unless discussed with the investigator and approved for registration.
* Systemic corticosteroids were continued to control symptoms of brain metastases at a total daily dose of \>2mg dexamethasone (or equivalent). However, patients with chronic stable doses ≤2mg daily of dexamethasone (or equivalent) may be discussed and approved by the investigator.
* Any brain lesion deemed to require immediate local treatment, including (but not limited ) increased lesion size at anatomical sites or possible treatment-related edema, may pose a risk to the patient (e.g.brain stem lesions). Patients received local treatment were still eligible for study based on lesions identified by screening contrast brain MRI according to the criteria described in the CNS inclusion criteria.
* More than 2 seizures within 4 weeks before enrollment.
* Poor control of hypertension; Or a previous history of hypertensive crisis or hypertensive encephalopathy.
* Patients had a history of hemoptysis within 6 months before enrollment. Or evidence of bleeding tendency or significant coagulopathy within the past 1 month.
* Currently receiving full-dose warfarin or equivalent, or aspirin (325mg/ day) within 10 days
* The need for major surgery, open biopsy, or major trauma was anticipated within 28 days or during the course of the study.
* Patients with a history of abdominal fistula or gastrointestinal perforation within the previous 6 months; The presence of an unhealed wound, active ulcer, or untreated fracture; Pregnant or lactating women.
* Patients with a history of psychotropic drug abuse and inability to abstain or with mental disorders.
* Other nonmalignant systemic diseases (cardiovascular, renal, liver, etc.) that were treated by any treatment regimen or prevented follow-up were excluded.
* Known or suspected allergies to any of the study drugs or excipients.
* No brain MRI for any reason.
* Any other condition considered by the investigator to be unsuitable for participation in the trial.
* Other situations in which corticosteroid use is prohibited.

Where this trial is running

Tianjin, Tianjin

• Yehui Shi — Tianjin, Tianjin, China (Recruiting)

Study contacts

• Principal investigator: Yehui Shi, MD,Phd — Tianjin Medical University Cancer Institute and Hospital
• Study coordinator: Yehui Shi, MD,Phd

Conditions Mammary Neoplasms, Human