Treatment for brain metastases in lung cancer patients with EGFR mutations

Prospective, Multicenter, Randomized Controlled, Phase III Clinical Study of Armatinib Alone or in Combination With Stereotactic Body Radiotherapy (SRT) for First-line Treatment of Brain Metastases From EGFR-mutated Non-small Cell Lung Cancer

This study is testing if a new drug called armatinib, alone or with targeted radiation therapy, can help lung cancer patients with brain metastases feel better and manage their symptoms.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Shanghai Cancer Hospital, China (Academic / other)
• Drugs / interventions: chemotherapy, radiation, armatinib, Almonertinib
• Locations: 1 site (Shanghai, Shanghai Municipality)
• Trial ID: NCT05800223 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness and safety of armatinib, both alone and in combination with stereotactic radiotherapy (SBRT), for patients with asymptomatic or minimally symptomatic Stage IV EGFR-positive non-small cell lung cancer (NSCLC) who have brain metastases. Participants will receive a daily oral dose of armatinib and undergo SBRT with a specified dosage regimen. The study aims to determine the optimal timing and outcomes of these treatments in managing brain metastases in this patient population.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with confirmed EGFR-positive NSCLC and measurable brain metastases who are asymptomatic or minimally symptomatic.

Not a fit: Patients with significant symptoms from brain metastases or those who have received prior systemic therapy beyond specified limits may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a new effective treatment option for patients with EGFR-positive NSCLC and brain metastases.

How similar studies have performed: Other studies have shown promising results with targeted therapies and radiotherapy for similar conditions, indicating potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. aged 18 years or older (including 18 years) and up to 75 years (including 75 years)
2. histologically confirmed NSCLC (by AJCC 8th edition lung cancer staging criteria)
3. asymptomatic or minimally symptomatic brain metastases (i.e., headache, nausea, or seizures responding to dexamethasone/analgesic/antiepileptic agents at a stable drug dose for at least 3 days);
4. brain metastases must meet the following criteria on diagnostic MRI: at least one lesion that can be classified as measurable disease according to RANO-BM, ≤ 10 brain or brainstem metastases
5. epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 (L858R) substitution mutation (alone or in combination with other EGFR mutations);
6. no prior systemic therapy other than neoadjuvant therapy, adjuvant therapy, or concurrent chemotherapy for more than 3 months prior to study entry
7. Eastern Cooperative Oncology Organization Group (ECOG) physical status score of 0 or 1 and no worsening in the previous 2 weeks, with a minimum expected survival of 12 weeks.
8. good hematopoietic function, defined as absolute neutrophil count ≥ 1.5 × 109 /L, platelet count ≥ 100 × 109 /L, and hemoglobin ≥ 90 g/L \[no transfusion or erythropoietin (EPO-dependent) within 7 days
9. good coagulation, defined as an international normalized ratio (INR) or prothrombin time (PT) ≤ 1.5 times ULN; if the subject is on anticoagulation therapy, as long as the PT is within the proposed range of anticoagulant medication
10. good liver function, defined as a total bilirubin level ≤ 1.5 times the upper limit of normal (ULN); glutathione transaminase (AST) and glutamate transaminase (ALT) levels ≤ 2.5 times the ULN for patients without liver metastases; and AST and ALT levels ≤ 5 times the ULN for patients with documented liver metastases
11. good renal function, defined as serum creatinine ≤ 1.5 times ULN or calculated creatinine clearance ≥ 60 ml/min; urine protein less than 2+ on routine urine examination, or 24-hour urine protein quantification \< 1 g
12. Women of childbearing potential should have a negative urine or serum pregnancy test within 3 days prior to receiving the first dose of study drug (Week 1, Day 1).
13. male patients should be using barrier contraception (i.e., condoms) from screening until 6 months after discontinuation of study treatment
14. Subjects will voluntarily participate and sign an informed consent in writing.

Exclusion Criteria:

1. Received any of the following treatments:

   1. Currently participating in an interventional clinical study treatment or received another study drug within 4 weeks prior to the first dose
   2. Received palliative intracranial radiation therapy prior to the first dose
   3. Patient has undergone major surgery (including biopsy) or major trauma within 4 weeks prior to the first dose of study drug; patients who are expected to require major surgery during the study period
   4. Patients previously treated with EGFR-TKI.
2. patients with NSCLC EGFR driver gene negative or known severe allergic reactions (≥ grade 3) to TKIs drugs;
3. patients who are unable to undergo MR examination
4. brain metastases requiring surgical decompression;
5. the presence of a previous solid organ or hematologic transplant; clinically active diverticulitis, abdominal abscess, gastrointestinal obstruction; the presence of clinically uncontrollable pleural effusion/peritoneal effusion
6. malignancy other than non-small cell lung cancer within 5 years prior to enrollment, excluding adequately treated carcinoma in situ of the cervix, basal cell or squamous epithelial cell skin cancer of the skin, localized prostate cancer after radical surgery, and ductal carcinoma in situ of the breast;
7. having unremitting residual toxicity of prior therapy greater than CTCAE grade 1 at the time of initiation of study treatment, with the exception of alopecia and grade 2 neurotoxicity from prior chemotherapy;
8. have any serious or poorly controlled systemic disease, such as active bleeding-prone body or active infection, as judged by the investigator. Chronic illnesses that do not require exclusion;
9. the known presence of a psychiatric illness or substance abuse condition that may have an impact on compliance with trial requirements
10. any serious or uncontrolled ocular pathology that, in the judgment of the physician, may increase the safety risk to the patient
11. a known history of human immunodeficiency virus (HIV) infection (i.e., HIV 1/2 antibody positive)
12. patients who, in the judgment of the investigator, are likely to be poorly compliant with the procedures and requirements of the study.

Where this trial is running

Shanghai, Shanghai Municipality

• Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China (Recruiting)

Conditions Non-small Cell Lung Cancer Metastatic