Treatment for anxiety in older adults with mild Alzheimer's

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial tests the effectiveness of a computerized anxiety sensitivity treatment (CAST) compared to a health education control (HEC) for older adults with mild cognitive impairment or mild Alzheimer's Disease and their care partners. Participants will undergo a series of assessments and interventions over six in-person visits, including neuropsychological evaluations and ecological momentary assessments. The study aims to reduce anxiety symptoms in patients and alleviate care partner burden through guided sessions and follow-up evaluations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

DYAD

* Patient age 60+
* Care partner 18+
* Has care partner who will participate ("someone you have a reciprocal relationship with who provides you with emotional or physical support and helps with decision-making. This could be a spouse or significant other, relative, or close friend whom you spend a significant amount of time with.")
* Has smartphone or access to Wi-Fi

EITHER

* Score of 20 or above on the PROMIS-Anxiety short form (patient only) OR
* Score of 5 or above on SSASI (patient only) OR
* Score of 31 or above on NIH Toolbox Perceived Stress Scale score (patient only)

AND EITHER

1. Participant MoCA score is between 17 to 26

   OR
2. Participant Memory Complaint Scale score 3 or greater

   OR
3. Care partner quick dementia rating scale score between 2 to 12.5

Exclusion Criteria:

PATIENT

* Issues with seeing or hearing that would prevent reading or listening to computer presentations
* Medical conditions that would preclude participation in study
* Severe mental illness (e.g., schizophrenia, unmedicated bipolar disorder)

CARE PARTNER

* Issues with seeing or hearing that would prevent reading or listening to computer presentations
* Medical conditions that would preclude participation in study
* Severe mental illness (e.g., schizophrenia, unmedicated bipolar disorder)

Where it's running

• Anxiety and Behavioral Health Clinic
  Tallahassee, Florida, United States Recruiting
• Ohio University
  Athens, Ohio, United States Recruiting
• The Ohio State University
  Columbus, Ohio, United States Recruiting

Study contacts

• Study coordinator: Norman B Schmidt, Ph.D.
• Email: schmidt@psy.fsu.edu
• Phone: 8506451766

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.