Treating obstructive sleep apnoea in people with difficult-to-control asthma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an open-label, randomized controlled trial enrolling adults with difficult-to-control asthma who undergo home sleep testing for obstructive sleep apnoea (OSA). Participants found to have OSA are randomized to CPAP treatment or no CPAP, while those without OSA form a reference group. The study will compare asthma control, symptom burden, and quality of life as primary outcomes, with secondary outcomes including exacerbation rates, sleep quality, and healthcare use. Participants are recruited from Difficult Asthma clinics and must be on GINA step 4–5 therapy and meet other eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients must have a clinical diagnosis of asthma with supportive objective diagnostics including but not limited to, variable airflow obstruction, bronchial-hyper responsiveness and demonstrable eosinophilic inflammation via fractional exhaled nitric oxide or peripheral eosinophilia
* Patients receiving step 4 or step 5 of 'The Global Initiative for Asthma' (GINA) treatment guidelines will be selected
* Between the ages of 18 to 90 years of age

Exclusion Criteria:

* Patients with previous sleep study investigations
* Excessive daytime sleepiness; ESS \>17
* Previous diagnosis of a sleep disorder
* Resting hypoxaemia or need for long-term oxygen therapy
* Inability to provide informed consent

Where it's running

• St. James's Hospital
  Dublin, Dublin, Ireland Recruiting

Study contacts

• Study coordinator: Laura Piggott, BM BS BSc MSc
• Email: laurampiggott@gmail.com
• Phone: +353876801786

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.