Treating infected non-vital baby molars with a zinc oxide/6-gingerol mix versus a triple antibiotic paste
Comparative Evaluation of Clinical and Radiographic Outcomes of Lesion Sterilization and Tissue Repair Using Zinc Oxide/ 6-gingerol Mix Versus Triple Antibiotic Paste in Non-vital Primary Molars: A Randomized Clinical Trial
This trial will test whether a zinc oxide/6-gingerol mix or a triple antibiotic paste better cleans and heals infected non-vital primary molars in children aged 4 to 8.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 4 Years to 8 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07488416 on ClinicalTrials.gov |
What this trial studies
This interventional study compares Lesion Sterilization and Tissue Repair (LSTR) using a zinc oxide/6-gingerol mixture versus a conventional triple antibiotic paste in non-vital primary molars. Children aged 4–8 with at least two restorable non-vital primary molars and periapical radiolucency will receive minimal canal instrumentation followed by placement of one of the two medicaments. Clinical signs (pain on mastication, mobility, resolution of symptoms) and radiographic changes (periapical radiolucency, root resorption) will be recorded at scheduled follow-ups to compare healing. The trial is conducted at Al-Azhar University in Cairo to determine whether the zinc oxide/6-gingerol mix can match or improve outcomes compared with the antibiotic paste.
Who should consider this trial
Good fit: Children aged 4 to 8 who have at least two restorable non-vital primary molars with periapical radiolucency and symptoms such as pain on chewing, pathological mobility, or internal/external root resorption are ideal candidates.
Not a fit: Children with systemic diseases, teeth near natural exfoliation, teeth with vital pulps, or teeth with furcation involvement extending to the developing permanent tooth germ are unlikely to benefit from this treatment.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive alternative that helps save infected baby molars and avoid extractions.
How similar studies have performed: Previous reports of LSTR using antibiotic mixtures have demonstrated clinical and radiographic success, while zinc- or herbal-based alternatives like 6-gingerol have been less extensively studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 4 to 8 years. * Both sexes * Children must have at least two restorable non-vital primary molars * Periapical radiolucency. * Pain on mastication. * Pathological mobility. * Internal or external root resorption. * Furcation involvement should not extend to the developing tooth germ. Exclusion Criteria: * Presence of systemic diseases. * Teeth with physiological mobility near exfoliation time. * Teeth with vital pulp.
Where this trial is running
Cairo
- Al-Azhar University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Ahmed E El-Metwally, MBBCH
- Email: ahmedalsaayed647@gmail.com
- Phone: 00201090888701
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.