Treating depression in narcolepsy patients with brain stimulation
Treating Comorbid Depression of Patients With Narcolepsy by Intermittent Theta Burst Stimulation: A Preliminary Study
This study is testing if a special brain stimulation can help people with narcolepsy who also have depression feel better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 105 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Taoyuan) |
| Trial ID | NCT05884112 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the effectiveness of intermittent theta burst stimulation in treating comorbid depression in patients with narcolepsy. It involves collecting comprehensive brain imaging and HLA typing data from narcoleptic patients and non-narcoleptic controls to identify distinguishing characteristics. The study will utilize machine learning to develop predictive models for narcolepsy diagnosis and treatment. A total of 400 subjects aged 9 to 45 will be recruited, divided into groups based on narcolepsy type and control status.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18-60 diagnosed with Type 1 or Type 2 narcolepsy who also experience comorbid depression.
Not a fit: Patients with epilepsy, severe brain injuries, or other serious mental disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved treatment options for patients suffering from both narcolepsy and depression.
How similar studies have performed: While there have been studies on narcolepsy and depression, the specific use of intermittent theta burst stimulation in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Meet the diagnosis of Type 1 or Type 2 sleep disorder, and comorbid with depression. 2. The age is introduced between 18-60 years old, regardless of gender. 3. Those who agree to participate in the trial and sign the subject's consent form. Exclusion Criteria: 1. Combined with epilepsy, brain injury or severe organic brain disease or serious heart disease. 2. Combined with serious other mental disorders, such as bipolar disorder, mental retardation or addiction disorders. 3. Not willing to participate in this study or not willing to fill out the consent form. 4. Those who are not suitable to enter the experiment after being evaluated by PI and co PI.
Where this trial is running
Taoyuan
- Chang-Gung Memorial Hospital — Taoyuan, Taiwan (Recruiting)
Study contacts
- Study coordinator: Yu-shu Huang
- Email: yushuhuang1212@gmail.com
- Phone: +886 3 3281200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.