Treating Baker Cysts in Knee Osteoarthritis with PRP Injection
Ultrasound-guided Baker Cyst Aspiration Combined with Platelet-rich Plasma Injection in Knee Osteoarthritis: a Randomised Clinical Trial
This study tests if combining a procedure to remove fluid from Baker cysts with a special injection can help people with knee osteoarthritis feel less pain and improve their knee function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Izmir Katip Celebi University Academic / other |
| Locations | 1 site (Izmir) |
| Trial ID | NCT06605560 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of combining Baker cyst aspiration with platelet-rich plasma (PRP) injection in patients suffering from knee osteoarthritis. It aims to assess the impact of this combined approach on pain, function, and the size of the cyst compared to aspiration alone. The study includes patients diagnosed with grade 1-3 knee osteoarthritis and a Baker cyst measuring over 1 cm. The methodology involves imaging techniques to confirm the presence of the cyst and monitor outcomes post-treatment.
Who should consider this trial
Good fit: Ideal candidates are individuals with grade 1-3 knee osteoarthritis and a Baker cyst larger than 1 cm.
Not a fit: Patients with grade 4 knee osteoarthritis or those with secondary causes for Baker cysts will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce pain and improve quality of life for patients with knee osteoarthritis and Baker cysts.
How similar studies have performed: While previous studies have explored aspiration and corticosteroid treatments for Baker cysts, the use of PRP injection in this context is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of grade 1-2-3 knee osteoarthritis according to Kellgren Lawrence classification * Presence of a baker cyst (popliteal cyst) with at least one of the width or length measurements \>1 cm (proven by magnetic resonans imaging or muskuloskeletal ultrasound examination) Exclusion Criteria: * Patients with grade 4 knee osteoarthritis according to the Kellgren Lawrence classification * Presence of secondary causes other than gonarthrosis which may lead to the development of a Baker cyst, such as meniscopathy, rheumatic diseases or anterior cruciate ligament damage, etc. * Long-term use (more than 3 months) of corticosteroid-containing medication * History of hyaluronic acid injection into the knee within the last 6 months or corticosteroid injection within the last 3 months * Skin lesions in and around the knee area in the last 7 days * Current Hb value \<12 or platelet value \<150,000 * Immunologic or connective tissue disease * Patients with lateral knee joint space narrowing more than medial * History of previous knee surgery * History of pregnancy or breastfeeding
Where this trial is running
Izmir
- Izmir Katip Çelebi University — Izmir, Turkey (Recruiting)
Study contacts
- Principal investigator: Ayhan Aşkın, Professor — Izmir Katip Çelebi University
- Study coordinator: Ayhan Aşkın, Professor
- Email: ayhan.askin@ikcu.edu.tr
- Phone: +902322444444
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.