Transoral and neck ultrasound to find suspected oropharyngeal (throat) cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial is a randomized controlled study that will enroll 170 adults with suspected oropharyngeal cancer across multiple head and neck departments in Denmark. Participants are randomized to receive either standard diagnostic workup or standard workup plus transoral and cervical (neck) ultrasound of the palatine and lingual tonsils using high-frequency transducers. The study will compare diagnostic accuracy, the number of correct biopsies, the number of additional imaging tests ordered, and time to final diagnosis between the two groups. The goal is to determine whether adding this ultrasound approach changes clinical decision-making and patient pathways compared with current practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Referred to outpatient cancer clinic with one of the following:

* A scan (MR, CT, PET/CT) suggesting malignancy in the oropharynx. This being asymmetric metabolic activity on PET/CT, a tumor or asymmetry of the palatine and lingual tonsils on MR and CT (7).
* Tumor suspicious findings (erosion/ulcus, tonsil asymmetry/hypertrophy).
* Tumor-suspicious symptoms (pain of the oropharynx)

  * \> 18 years of age.
  * Ability to understand and give informed consent.

Exclusion Criteria:

* • Prior oropharyngeal cancer

  * Prior radiation to the head and neck area

Where it's running

• Department of Otorhinolaryngology, Head and Neck Surgery & Audiology
  Copenhagen, Denmark Recruiting
• Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital
  Aarhus, Denmark Not yet recruiting
• Department of Otorhinolaryngology, Head and Neck Surgery & Audiology Northzealand Hospital
  Hillerød, Denmark Not yet recruiting
• Department of ORL - Head & Neck Surgery and Audiology, Zealand University Hospital,
  Køge, Denmark Not yet recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ultrasound-guided nasal bone fracture reduction

  This study tests whether using ultrasound to guide nasal bone fracture reduction can improve accuracy and outcomes for people with recent nasal injuries.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07869563

• Intraoperative Methadone for Postoperative Pain in Head and Neck Cancer Patients

  This trial tests whether giving methadone during surgery, in addition to standard fentanyl, helps control pain after head and neck cancer surgery more effectively than fentanyl alone.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07857655

• Inter-rater Test of Rectus Abdominis Thickness on Ultrasound After BFR Training

  This study checks if different readers measure the thickness of the rectus abdominis on ultrasound the same way after a blood flow restriction workout.

  Recruiting Riphah International University · Islamabad · NCT07754162

• Mild heat therapy added to standard treatment for locally advanced head and neck cancer

  This early-stage trial tests whether mild hyperthermia can be safely added to standard radiotherapy with or without chemotherapy for locally advanced head and neck cancer.

  Recruiting Phase 1 Erasmus Medical Center · Rotterdam, South Holland · NCT07690618

• How the core and shoulder function relate in people with chronic low back pain

  This study tests whether core stability and Transversus Abdominis (TrA) involvement affect upper body reach and scapular control in adults with chronic low back pain compared with healthy individuals.

  Recruiting Istanbul Saglik Bilimleri University · Ankara · NCT07474610

• Teaching anesthesiologists ultrasound-assisted neuraxial access for spinal anesthesia

  This trial will test whether training anesthesiologists to use ultrasound for spinal anesthesia improves clinical outcomes and patient satisfaction for adults having elective lower limb surgery.

  Recruiting University of Southern Denmark · Kolding and 1 other locations · NCT07426679

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.