Translesional pressure measurements to see whether a mesenteric artery narrowing causes symptoms.
Official title: Translesional PRESSURE Measurements to Assess Clinical Relevance of a Mesenteric Artery Stenosis (PRESSURE-study)
Run by Erasmus Medical Center · NCT07059520 · Data updated 2026-11-12
This study will test whether measuring the pressure across a narrowed mesenteric artery helps identify which adults with chronic mesenteric ischemia who are scheduled for endovascular treatment will benefit from treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 125 (estimated) |
| Sponsor | Erasmus Medical Center Academic / other |
| Locations | 3 sites (Enschede, Overijssel and 2 other locations) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | July 1, 2027 |
| Study ends | January 1, 2028 |
| Registry record updated | July 31, 2025 |
| Trial ID | NCT07059520 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) with chronic mesenteric ischemia who are scheduled for an endovascular procedure of the mesenteric arteries and can give informed consent are the intended participants.
✕Probably not a fit
Patients with acute mesenteric ischemia, normal vascular anatomy variants (common origin of SMA and CA), those unable to consent, pregnant people, or those not undergoing endovascular treatment are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, multicenter study in which pressure measurements (Pd/Pa or similar translesional metrics) are taken across mesenteric artery stenoses during planned endovascular procedures. Investigators will compare these hemodynamic measurements with imaging, clinical history, and functional test findings and will follow patient-reported symptom relief after revascularization. The goal is to determine whether pressure-guided information better predicts symptomatic improvement than imaging alone. The study includes adult patients with chronic mesenteric ischemia undergoing endovascular management at participating Dutch centers.
Why it matters
Potential benefit: If successful, this approach could help avoid unnecessary procedures and improve the chance that patients treated for mesenteric artery narrowing actually experience symptom relief.
How similar studies have gone: Pressure-based (Pd/Pa/FFR-like) methods have been successful and widely adopted in coronary disease and have some supportive retrospective data in mesenteric disease, but prospective validation for mesenteric stenoses is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with chronic mesenteric ischemia (CMI) and scheduled for endovascular procedure of the mesenteric arteries * Age ≥18 years of age * Patients who gave informed consent Exclusion Criteria: * Patients presenting with acute mesenteric ischemia * Common origin of the SMA and CA (normal variant) * Patients unable to give informed consent * Pregnancy * Other criteria the physician considers not compatible with this study
Where it's running
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Erasmus University Medical Centre Rotterdam
Rotterdam, South Holland, Netherlands Recruiting -
Franciscus
Rotterdam, South Holland, Netherlands Recruiting -
Medisch Spectrum Twente
Enschede, Overijssel, Netherlands Not yet recruiting
Study contacts
- Study coordinator: Eva Karina Bocharewicz, PhD Candidate
- Email: e.bocharewicz@erasmusmc.nl
- Phone: +31652216196
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.