Transcutaneous versus blood CO2 monitoring in critically ill children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study in a pediatric intensive care unit comparing paired transcutaneous CO2 (tPCO2) readings with arterialized or arterial blood gas PaCO2 values in children aged 1–18 with respiratory insufficiency. Paired measurements will be analyzed using Bland–Altman methods with correction for repeated measures to quantify agreement. Subgroup analyses will examine the effect of vasopressor therapy and peripheral perfusion on tPCO2 accuracy, and secondary analyses will compare transcutaneous and arterial oxygen measurements (tPO2 vs PaO2). The goal is to define when transcutaneous capnometry can be used reliably and what its limitations are in critically ill pediatric patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 1-18 years
* Diagnosis of respiratory insufficiency or impaired peripheral perfusion
* Expected need for more than one arterialized capillary or arterial blood gas sample
* Admission to PICU

Exclusion Criteria:

* Repeated failure of sensor adhesion
* Hypothermia \< 35 °C
* Time difference \> ±5 minutes between tPCO₂ and blood sampling
* Large tPCO₂ variability (\> ±1 kPa) in 15 minutes preceding blood sampling
* Non-physiological tPCO₂ values incompatible with life

Where it's running

• University Hospital Brno
  Brno, Czechia Recruiting

Study contacts

• Study coordinator: Hana Harazim, MD, PhD
• Email: hana.harazim@gmail.com
• Phone: +420777146704

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.