Transanal versus Transvaginal rectal resection for anterior rectocele
Official title: Outcomes of Transanal Versus Transvaginal Rectal Resection for Anterior Rectocele: A Randomized Controlled Trial
Run by Cairo University · NCT07375147 · Data updated 2026-11-12
This project will test two surgical techniques—stapled transanal and stapled transvaginal rectal resection—to see which better relieves obstructed defecation in women with anterior rectocele.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 62 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo, Al-Manial, Cairo, Egypt) |
| Status | Recruiting |
| Started | June 14, 2025 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | May 22, 2026 |
| Trial ID | NCT07375147 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult women with symptomatic obstructed defecation due to an anterior rectocele ≥3 cm on straining who have failed conservative management and meet other eligibility criteria are ideal candidates.
✕Probably not a fit
Patients with slow-transit constipation, rectocele <3 cm, complete external rectal prolapse, inflammatory bowel disease, colorectal cancer, prior rectal or rectocele surgery, or inability to follow postoperative recommendations are unlikely to benefit from these procedures in this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial enrolls adult women with obstructed defecation due to an anterior rectocele of at least 3 cm who have failed conservative treatment. After consent and preoperative workup including defecography and anorectal examination, participants are randomized 1:1 to receive either stapled transanal rectal resection or stapled transvaginal rectal resection performed by experienced colorectal surgeons. The primary outcome is change in obstructed defecation symptoms measured by the Cleveland Clinic Constipation (CCC) score, with secondary outcomes including operative time, postoperative pain, continence status, complications, and length of hospital stay. Outcomes and complication rates will be compared between the two groups over the postoperative follow-up period.
Why it matters
Potential benefit: If one technique proves superior, patients could gain better symptom relief, fewer complications, and faster recovery after surgery.
How similar studies have gone: Both stapled transanal (STARR) and transvaginal repairs have been used in prior cohorts and some trials with symptom improvement reported, but direct randomized comparisons remain limited and results have been mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult female patients complaining of obstructed defecation syndrome with anterior rectocele ≥ 3 cm on straining with failure of conservative management. Exclusion Criteria: * Patients with Slow-transit constipation * Patients with rectocele of \< 3 cm on straining * Patients with complete external rectal prolapse * Evidence of colorectal carcinoma or Inflammatory bowel disease ( IBD) * Previous rectal surgeries * Inability for lifestyle change postoperatively * Previous surgeries for anterior rectocele
Where it's running
-
Faculty of medicine, Cairo University
Cairo, Al-Manial, Cairo, Egypt, Egypt Recruiting
Study contacts
- Study coordinator: Ahmed Mohamed Abdelaal, Lecturer
- Email: drabdelaal90@gmail.com
- Phone: +201118732767
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.