Training working memory in older adults with mild cognitive impairment
Working Memory Training and Neural Plasticity in Mild Cognitive Impairment
This study is testing whether working memory training can help older adults with mild cognitive impairment improve their thinking skills.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | University of Michigan Academic / other |
| Locations | 1 site (Ann Arbor, Michigan) |
| Trial ID | NCT05380739 on ClinicalTrials.gov |
What this trial studies
This pilot study evaluates the effectiveness of working memory training in older adults diagnosed with amnestic mild cognitive impairment (MCI). It aims to understand the impact of this training on cognitive abilities and the underlying neural mechanisms involved. Participants will undergo behavioral assessments and brain imaging techniques, including fMRI and fNIRS, to measure changes in learning and memory. The study will also include cognitively intact older adults as a control group to compare results.
Who should consider this trial
Good fit: Ideal candidates for this study are older adults diagnosed with amnestic mild cognitive impairment who are right-handed and eligible for MRI.
Not a fit: Patients with significant mental illness, other neurological conditions affecting cognition, or sensory impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance cognitive functioning in older adults with mild cognitive impairment, potentially delaying the progression to more severe dementia.
How similar studies have performed: Other studies have shown promise in using cognitive training to improve memory function in older adults, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * MCI Diagnosis * Right-handedness * MRI-eligibility for MRI participants Exclusion Criteria: * History of other contributing neurological or medical conditions known to affect cognitive functioning * Significant mental illness * Sensory impairments that limit ability to participate * History of alcohol or drug abuse/dependence
Where this trial is running
Ann Arbor, Michigan
- University of Michigan — Ann Arbor, Michigan, United States (Recruiting)
Study contacts
- Principal investigator: Alexandru Iordan, Ph.D. — University of Michigan
- Study coordinator: Alexandru Iordan, Ph.D
- Email: adiordan@umich.edu
- Phone: 734-764-2909
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.