Training to strengthen breathing muscles in patients with post-COVID syndrome
The Effects of Based-home High-resistance Inspiratory Muscle Training on Neurovascular Control, Blood Pressure, and Exercise Capacity in Patients With Post-COVID-19 Syndrome
This study is testing if a special breathing exercise can help people with post-COVID syndrome improve their heart health and reduce stress on their bodies.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | D'Or Institute for Research and Education Academic / other |
| Locations | 1 site (São Paulo) |
| Trial ID | NCT06091384 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of high resistance inspiratory muscle strength training (IMST) on patients suffering from post-COVID-19 syndrome, who are at increased risk for cardiovascular diseases. Participants will engage in IMST at home, performing sessions of 5 minutes, 5-7 times a week for 6 weeks. The primary goal is to determine if this training can reduce sympathetic nerve activity, improve vascular function, and enhance overall cardiovascular health in these patients. The study is based on previous findings that suggest IMST can positively impact cardiovascular outcomes in various populations.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with post-COVID-19 syndrome who experienced severe symptoms requiring hospitalization and oxygen support.
Not a fit: Patients with chronic obstructive pulmonary disease, significant cardiovascular or renal diseases prior to COVID-19, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly improve cardiovascular health and reduce the risk of mortality in patients recovering from COVID-19.
How similar studies have performed: Previous studies have shown positive outcomes with inspiratory muscle strength training in various populations, suggesting potential success for this approach in post-COVID patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Post-COVID-19 syndrome * Have been diagnosed with COVID-19 by RT-PCR * Have oxygen saturation ≤ 93% in room air during the acute phase of the COVID-19 * Have received oxygen supply from any device during the acute phase of the COVID-19 * Hospitalization to treat the Covid-19 * Participants in cardiopulmonary rehabilitation or physical conditioning programs Exclusion Criteria: * Pregnant * History of chronic obstructive pulmonary disease or dependence on oxygen support * History of cardiovascular and renal diseases and cancer prior to the COVID-19 diagnosis * Difficulties in moving to the laboratory for assessments
Where this trial is running
São Paulo
- D'Or Institute of Research and Education — São Paulo, Brazil (Recruiting)
Study contacts
- Study coordinator: Allan R Sales, PhD
- Email: allan.sales@idor.org
- Phone: 55 21 996482036
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.