Training to improve balance and walking in multiple sclerosis patients
Examination of the Implications of Plantar Sensitivity Training and Aerobic Exercise Training on Balance, Functional Capacity, Gait and Proprioception in Patients With Multiple Sclerosis
This study is testing if adding sensory training to regular exercise can help people with multiple sclerosis improve their balance and walking skills.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Istanbul Arel University Academic / other |
| Locations | 1 site (Istanbul, Zeytinburnu) |
| Trial ID | NCT05937971 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of combining plantar sensory training with aerobic exercise in enhancing balance, functional capacity, walking ability, and proprioception in patients with multiple sclerosis. Participants will engage in conventional exercises along with aerobic training, while also receiving specific plantar sensory training. The study will assess whether the addition of sensory training provides significant benefits over aerobic exercise alone. The research is grounded in the understanding that sensory dysfunction in multiple sclerosis can impact balance and mobility.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-65 diagnosed with multiple sclerosis, exhibiting specific sensory deficits and functional limitations.
Not a fit: Patients with other significant health issues, such as pulmonary, orthopedic, or cardiovascular diseases, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved balance and mobility for patients with multiple sclerosis, potentially reducing fall risk and enhancing quality of life.
How similar studies have performed: While there are limited studies on plantar sensory training, similar approaches in other patient populations have shown positive effects on balance and mobility.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * being between the ages of 18-65 * Being diagnosed with multiple sclerosis according to McDonald's criteria * EDSS (Expanded Disability Status Scale) score between 3 and 5.5 * Stage 3/4/5 according to functional ambulation classification * Being able to ambulatory 100 meters independently or with device assistance * Not having an attack in the last 3 months * No change in routine treatment for MS (multiple sclerosis) in the past 3 months * Presence of plantar sensitivity loss (as measured with Semmes-Weinstein monofilaments) * having a plantar sensory threshold value higher than 2,83-3.61 for 1st metatarsal head; * 2.83-3.61 for 2-3rd metatarsal heads; * 2.83-3.61 for 4-5th metatarsal heads; * 3.61-4.08 for the lateral and medial heel)(15) * Decreased functional capacity (6-minute walking test distance F\<593±57meters, M\<638±44meters) (16) Exclusion Criteria: * Being diagnosed with pulmonary, orthopedic or cardiovascular disease * having diabetic neuropathy * Having neurological disease other than multiple sclerosis * Having a diagnosis of root compression, radiculopathy, lumbar disc herniation or complaining of low back pain for the last 3 months(17) * Using an ankle-foot orthosis (AFO) * Having cognitive dysfunction (MoCA score \<21)
Where this trial is running
Istanbul, Zeytinburnu
- Istanbul Arel University — Istanbul, Zeytinburnu, Turkey (Recruiting)
Study contacts
- Principal investigator: Nazlı Güngör, PT, MSc — Istanbul Arel University
- Study coordinator: Nazlı Güngör, PT, MSc
- Email: nazligungor@arel.edu.tr
- Phone: +905398659517
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.