Training for better diagnosis of lung diseases using cryobiopsy

Learning Curve for the Diagnosis of Interstitial Lung Disease by Transbronchial Lung Cryobiopsy and the Role of Standardized Training in It

NA · China-Japan Friendship Hospital · NCT06245954

This study is testing whether special training for doctors on a lung biopsy technique can help them diagnose lung diseases more accurately.

Quick facts

PhaseNA
Study typeInterventional
Enrollment20 (estimated)
Ages18 Years and up
SexAll
SponsorChina-Japan Friendship Hospital (other)
Locations1 site (Beijing, Beijing Municipality)
Trial IDNCT06245954 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of standardized training methods, including simulator and in vitro lung training, for physicians performing transbronchial lung cryobiopsy (TBLC). It aims to assess the learning curve of these physicians and determine how structured training can improve diagnostic accuracy for interstitial lung disease (ILD). The study is designed as a prospective randomized controlled trial to ensure robust results. Participants will be monitored for their performance in TBLC after undergoing different training approaches.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older with suspected interstitial lung disease and specific pulmonary function criteria.

Not a fit: Patients with severe coagulopathy or those who refuse to participate in the study may not benefit from this intervention.

Why it matters

Potential benefit: If successful, this study could enhance the diagnostic capabilities of physicians, leading to more accurate and timely diagnoses of interstitial lung disease.

How similar studies have performed: While the specific approach of standardized training in TBLC is novel, similar training methodologies in other medical procedures have shown promising results in improving physician performance.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥18 years
* suspected ILD.
* ≤3 months since HRCT
* Forced vital capacity (FVC) ≥50% of predicted value
* Diffused lung carbon monoxide (DLCO) ≥35% predicted value
* Echocardiography ≤ 12 months
* Estimated pulmonary artery systolic pressure ≤40 mmHg
* Body mass index (BMI) ≤35 kg/m2
* Patient consent for experimentation

Exclusion Criteria:

* Patients with platelet counts less than 50 × 109/L or prothrombin time international normalized ratio (INR) higher than 1.5
* Patients refused to participate in the experiment

Where this trial is running

Beijing, Beijing Municipality

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Transbronchial Lung Cryobiopsy, transbronchial lung cryobiopsy, standardized training, learning curve, bronchoscopist

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.