Training cognitive skills using neurofeedback after a stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the ability of stroke patients to learn self-regulation of their brain activity through real-time functional MRI neurofeedback (rt-fMRI NF). It focuses on patients who have experienced a first-ever ischemic stroke and are suffering from cognitive impairments. The intervention involves cognitive remediation therapy and neuropsychological assessments, alongside fMRI sessions to monitor brain activity. The goal is to enhance cognitive functions by targeting specific brain networks associated with cognitive decline post-stroke.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men or women
* Right handed
* 18 ≤ years old \< 75
* first-ever ischemic stroke on brain MRI in the past 3 to 6 months ;
* Persisting cognitive complaint 3 months after the ischemic stroke, proved by a MoCA score ≤ 26 (if educational level ≥ 12 years, or ≤ 25 if educational level \< 12 years), and involving at least one of the following cognitive domains : executive functions, attention, and processing speed ;
* Ischemic stroke located in the territory of the middle cerebral artery and /or basal ganglia/thalamus ;
* NIHSS ≤ 5, without aphasia or severe visual disability empeding the understanding of the instructions, the neurofeedback task achievement, and/or the neuropsychological assessment ;
* No prestroke disability defined by a modified Rankin Scale ≤ 2 ;
* For women of childbearing potential, use of effective contraception and negative pregnancy test.
* Written informed consent by the patient.
* Coverage by the French Social Insurance

Exclusion Criteria:

* Previous cognitive impairment ;
* History of psychiatric disorder ;
* Current use of psychotropic medication ;
* MRI contraindication ;
* Pregnancy or breastfeeding ;
* Chronic disease empeding the follow-up of the subject during the lenght of the study ;
* Non fluently-French speakers ;
* Patient under legal protection.
* Patient unable of giving personal consent
* Emergency situation
* 1st MRI incomplete, not performed or not analyzable

Where it's running

• CHU de Bordeaux
  Bordeaux, France Recruiting

Study contacts

• Principal investigator: Sharmila SAGNIER — University Hospital, Bordeaux
• Study coordinator: Sharmila SAGNIER, Dr
• Email: sharmila.sagnier@chu-bordeaux.fr
• Phone: 05 56 79 55 20

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.