Training caregivers to help teens with profound autism become more independent

Empowering Caregivers to Promote Child Independence and Persistence With Activities

Not applicable Interventional University of Nebraska · NCT07059364

This project will try picture-based activity schedules taught to caregivers to see if they help adolescents (10–17) with profound autism do activities more independently and give caregivers short breaks.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment32 (estimated)
Ages10 Years to 17 Years
SexAll
SponsorUniversity of Nebraska Academic / other
Locations1 site (Omaha, Nebraska)
Trial IDNCT07059364 on ClinicalTrials.gov

What this trial studies

Caregivers of adolescents with profound autism will be taught to use picture-based activity schedules (CAST) to increase the youths' independent, sustained engagement in meaningful activities. Participants will be assigned to receive caregiver training or continue usual routines, with families in the usual-routine group offered training after the trial. Investigators will measure children's task performance and caregivers' pre- and post-study ratings to judge feasibility and acceptability. The main aim is to determine whether this caregiver-delivered approach can reduce constant supervision demands and improve quality of life for both adolescents and caregivers.

Who should consider this trial

Good fit: Autistic adolescents aged 10–17 with severe or profound intellectual disability (DP-4 cognitive/communication scores below 70 and low ABAS-3 scores), who can complete 3–10 simple tasks with caregiver prompting and have at least one English-speaking caregiver available.

Not a fit: Those who cannot complete any simple leisure or daily living tasks independently, have unstable medical or behavioral conditions or planned changes in medications/services, or lack an English-speaking caregiver may not benefit from this intervention.

Why it matters

Potential benefit: If successful, the approach could increase adolescents' independent engagement in daily activities and give caregivers reliable short periods away from constant supervision.

How similar studies have performed: Previous caregiver-training and picture-schedule interventions have shown promise for improving independence in individuals with intellectual disability or limited verbal skills, but populations labeled as profound autism have been underrepresented in prior research.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Autistic individuals 10 to 17 years of age
* Severe or profound intellectual disability diagnosis or reportedly in line with diagnostic criteria based on Autism Diagnostic Observation Schedule, Second Edition ADOS-2
* Developmental Profile 4 (DP-4) Cognitive/Communication Domain scores below 70 (Delayed)
* Adaptive Behavior Assessment System (ABAS-3) Communication, Health and Safety, and Leisure Domains adaptive skill scores in the Low to Extremely Low range
* Can complete between 3-10 simple leisure or daily living skill tasks or activities independently (caregiver may prompt or provide oversight)
* Caregivers can remain present to assist with toileting if more than one person is needed to assist
* No medication or stable medication regimen with no planned changes for study duration
* Stable intervention and/or educational services with no planned changes for study duration
* English spoken by at least one caregiver

Exclusion Criteria:

* Known serious medical condition or serious behavioral/psychiatric condition requiring immediate alternative focused intervention

Where this trial is running

Omaha, Nebraska

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Profound AutismPicture-Based Activity SchedulesCaregiver Training
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.