Tracking PXE-related changes at the back of the eye over time

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This monocentric observational study at the University Eye Hospital Bonn follows people with PXE with repeated high-resolution optical coherence tomography and perfusion imaging. Investigators will quantify Bruch's membrane reflectivity, measure choriocapillaris flow deficits, and monitor the development and expansion of retinal atrophy over two years. Imaging features will be correlated with ABCC6 gene variants to explore genotype-phenotype relationships. The goal is to clarify the sequence of structural and perfusion changes and to identify imaging markers of progression.

Why it matters

Who can join: the full rules

Inclusion Criteria for PXE cohort:

* PXE based on the criteria of Plomp et al.
* Clear ocular media
* Ability to perform the tasks of the study protocol (i.e., holding the head still for image aquisition)

Exclusion Criteria:

* Any confounding ocular disease not associated with PXE
* Systemic diseases hindering the study examinations

Where it's running

• Department of Ophthalmology, University Hospital Bonn, Germany
  Bonn, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Study coordinator: Kristina Pfau, MD, FEBO
• Email: Kristina.Pfau@ukbonn.de
• Phone: +49 (0)228-287 15505

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.