Tracking outcomes of uterine cavity conditions after hysteroscopy
Official title: Cohort Study of Intrauterine Diseases
Run by Tongji Hospital · NCT07048327 · Data updated 2026-11-12
This project will follow adults with endometrial polyps, hyperplasia, or cancer who undergo hysteroscopy to see if detailed clinical and pathology data can predict disease course over one year.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | Women only |
| Enrollment | 2000 (estimated) |
| Sponsor | Tongji Hospital Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | July 2025 |
| Main results expected | July 2028 |
| Study ends | July 2028 |
| Registry record updated | July 2, 2025 |
| Trial ID | NCT07048327 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 who require hysteroscopy or diagnostic curettage for intrauterine pathology and are willing and able to provide informed consent and complete one-year follow-up.
✕Probably not a fit
People who cannot tolerate hysteroscopy, are actively enrolled in other drug trials, or cannot commit to the study follow-up are unlikely to receive benefit from this cohort.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective cohort platform enrolling patients undergoing hysteroscopy or diagnostic curettage for intrauterine lesions. Investigators will collect medical, menstrual, and obstetric histories, physical and gynecological exams, imaging, laboratory tests, and pathology results at baseline. After hysteroscopic surgery, participants will be followed for one year to document disease progression and outcomes. The platform aims to link clinical data with pathology to deepen understanding of pathogenesis, risk factors, and optimize treatment strategies.
Why it matters
Potential benefit: If successful, the platform could enable earlier detection, better risk stratification, and more tailored treatments for uterine cavity diseases.
How similar studies have gone: Other large observational cohorts of endometrial pathology have clarified risk factors and outcomes, so this effort applies established methods while adding prospective local data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18-80 years; * Patients requiring hysteroscopy or diagnostic curettage for intrauterine pathologies (e.g., endometrial hyperplasia, endometrial polyps, submucosal uterine fibroids, adenomyosis, or endometrial malignancies); * Willing and able to comply with follow-up requirements; * Signed informed consent obtained. Exclusion Criteria: * Concurrent participation in other drug clinical trials; * Contraindications to or inability to tolerate hysteroscopy/curettage procedures; * Unwilling or unable to provide informed consent; * Unwilling or unable to adhere to study protocols.
Where it's running
-
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China Recruiting
Study contacts
- Study coordinator: Wen W Wang, Dr.
- Email: petrawang@163.com
- Phone: +86 15927167698
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using ultrasound to guide endometrial biopsies for post-menopausal bleeding
This study is testing if using ultrasound to guide endometrial biopsies can help women with post-menopausal bleeding get better tissue samples and avoid more invasive procedures.
-
Fertility preservation for women with endometrial cancer and hyperplasia
This study is testing a new surgery to help younger women with early-stage endometrial cancer or hyperplasia keep their ability to have children instead of needing a hysterectomy.
-
Personalized navigation to support rural and Black women with endometrial cancer
This pilot tests a tailored patient-navigation program to help rural and Black patients with endometrial cancer access care and services.
-
CR-002 study in adults with advanced solid tumors
This trial tests CR-002 as a single therapy to see if it is safe and tolerable in adults with locally advanced or metastatic solid tumors
-
Methylation markers in self-samples to help detect gynecological cancers
This study tests whether self-collected urine and vaginal samples can reveal DNA methylation or other genetic markers that indicate endometrial, ovarian, vulvar, or vaginal cancers in women who are at risk or have postmenopausal bleeding.
-
One-Finger Technique to identify the left upper ureter during para-aortic lymphadenectomy
This study tests a new surgical method to help surgeons find the left upper ureter during open para-aortic lymphadenectomy in women with gynecologic cancers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.