Tracking iron rims around MS lesions over time

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows a cohort of MS patients who had susceptibility-weighted brain MRI scans between 2008 and 2012 and combines those historic images with new ultra-high-field (7T) and 3T MRI to track iron rim lesions over time. Participants provide blood samples for genotyping to look for genetic variants that might influence the formation or persistence of iron rim lesions. The team will correlate lesion evolution with clinical disability and disease progression measures to see whether iron rims predict a more severe course. Johns Hopkins collaborators and Nottingham University Hospitals will use standardized imaging reads and longitudinal clinical data to analyze lesion dynamics and genetic associations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged above 16 years
* Clinical diagnosis of MS as per revised McDonald Criteria 2017
* Existing susceptibility-weighted brain MRI scan
* Able to provide blood samples

Exclusion Criteria:

* Unwilling or unable to comply with the requirements of this protocol including the presence of any condition (physical, mental or social) that, in the opinion of the PI, is likely to affect the participants ability to comply with the study protocol.
* Unable to provide informed consent.

Where it's running

• Nottingham University NHS Trust
  Nottingham, United Kingdom Recruiting

Study contacts

• Study coordinator: Ryan Mamun
• Email: Ryan.Mamun1@nhs.net
• Phone: +447490225520

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.