Clinical trial Recruiting at 1 site Observational Ages 18 and up

Tracking central line bloodstream infections in Chinese ICUs

Official title: The First Phase of the Closed-loop Improvement Project for Preventing CLABSI

Run by Southeast University, China · NCT07255105 · Data updated 2026-11-12

This project will see how often and why central venous catheters cause bloodstream infections in adult ICU patients in China.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1846 (estimated)
SponsorSoutheast University, China
Academic / other
Locations1 site (Nanjing, Jiangsu)
StatusRecruiting
StartedJune 8, 2025
Main results expectedJanuary 31, 2026
Study endsSeptember 30, 2026
Registry record updatedNovember 28, 2025
Trial IDNCT07255105 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older admitted to the ICU at the enrolling site with a central venous catheter expected to remain in place more than 48 hours and who can provide informed consent are eligible.

Probably not a fit

Patients who had a central venous catheter for more than 24 hours before ICU admission, those readmitted to the ICU during the study period, pregnant or lactating women, or patients without a qualifying central line are not expected to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will enroll adults in the ICU who have a central venous catheter expected to remain in place for more than 48 hours and follow them until catheter removal or infection. Clinical, catheter, microbiology, and outcome data will be collected to calculate infection incidence per 1,000 catheter-days and to describe timing, pathogens, and associated outcomes. The work will compare incidence and outcomes with published benchmarks and analyze patient- and catheter-level risk factors for CLABSI. Results will quantify hospital stay, mortality, and additional costs associated with catheter-related bloodstream infections.

Why it matters

Potential benefit: If successful, the findings could clarify the burden and risk factors for CLABSI in Chinese ICUs and guide targeted prevention efforts to reduce infections, length of stay, and costs.

How similar studies have gone: Surveillance and prevention programs elsewhere, including prior Chinese and US reports, have reduced CLABSI rates, so using local epidemiology to guide prevention is an established approach though this specific dataset is from a single center.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 1\. Admitted to the ICU with a central venous catheter placed in place and the expected indwelling time exceeds 48 hours (including newly placed central venous catheters or the continued indwelling of existing qualified central venous catheters)

  2\. Patients aged 18 or above

  3\. Sign the informed consent form

Exclusion Criteria:

1. Patients who have had a central venous catheter indwelled for more than 24 hours before being admitted to the ICU (and are not going to have it replaced immediately)
2. Patients who were re-admitted to the ICU during the study period
3. Lactating and pregnant women

Where it's running

  • Zhongda Hospital Affiliated to Southeast University
    Nanjing, Jiangsu, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.