Tracking central line bloodstream infections in Chinese ICUs

The First Phase of the Closed-loop Improvement Project for Preventing CLABSI

This project will see how often and why central venous catheters cause bloodstream infections in adult ICU patients in China.

Quick facts

• Study type: Observational
• Enrollment: 1846 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Southeast University, China (Academic / other)
• Locations: 1 site (Nanjing, Jiangsu)
• Trial ID: NCT07255105 on ClinicalTrials.gov

What this trial studies

This observational project will enroll adults in the ICU who have a central venous catheter expected to remain in place for more than 48 hours and follow them until catheter removal or infection. Clinical, catheter, microbiology, and outcome data will be collected to calculate infection incidence per 1,000 catheter-days and to describe timing, pathogens, and associated outcomes. The work will compare incidence and outcomes with published benchmarks and analyze patient- and catheter-level risk factors for CLABSI. Results will quantify hospital stay, mortality, and additional costs associated with catheter-related bloodstream infections.

Who should consider this trial

Good fit: Adults aged 18 or older admitted to the ICU at the enrolling site with a central venous catheter expected to remain in place more than 48 hours and who can provide informed consent are eligible.

Not a fit: Patients who had a central venous catheter for more than 24 hours before ICU admission, those readmitted to the ICU during the study period, pregnant or lactating women, or patients without a qualifying central line are not expected to benefit from participation.

Why it matters

Potential benefit: If successful, the findings could clarify the burden and risk factors for CLABSI in Chinese ICUs and guide targeted prevention efforts to reduce infections, length of stay, and costs.

How similar studies have performed: Surveillance and prevention programs elsewhere, including prior Chinese and US reports, have reduced CLABSI rates, so using local epidemiology to guide prevention is an established approach though this specific dataset is from a single center.

Eligibility criteria

Inclusion Criteria:

* 1\. Admitted to the ICU with a central venous catheter placed in place and the expected indwelling time exceeds 48 hours (including newly placed central venous catheters or the continued indwelling of existing qualified central venous catheters)

  2\. Patients aged 18 or above

  3\. Sign the informed consent form

Exclusion Criteria:

1. Patients who have had a central venous catheter indwelled for more than 24 hours before being admitted to the ICU (and are not going to have it replaced immediately)
2. Patients who were re-admitted to the ICU during the study period
3. Lactating and pregnant women

Where this trial is running

Nanjing, Jiangsu

• Zhongda Hospital Affiliated to Southeast University — Nanjing, Jiangsu, China (Recruiting)

Study contacts

• Study coordinator: cai chenglong

Conditions CLABSI - Central Line Associated Bloodstream Infection